Systematic analysis of molecular synergy between folic acid and ferrous fumarate in iron deficiency anemia


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Abstract

This paper presents the results of a systems-biology analysis of synergy between iron and folates, the two micronutrients most commonly usedfor the nutritional support of pregnancy. Both folates and iron are essential for the biosynthesis and biological effects of glutathione. Analysis of the symptomatology and molecular pathophysiology of iron deficiency anemia (IDA) has shown that folates are an apparent iron synergist in erythropoiesis. Folate and iron deficiencies are characteristic of thyroid dysfunction and hyperglycemia. As shown by the example of ferrous fumarate when choosing medications for the treatment of IDA and for the prevention of iron deficiency in a pregnant woman, it is necessary to take into account the important pharmaceutical characteristics of the iron substances used. Conclusion: The advantages of the pharmaceutical substance of ferrous fumarate include high safety, high bioavailability of iron and proven efficacy in the treatment of IDA. The combination of ferrous fumarate and folic acid cannot only compensate for iron deficiency, but can also support the processes of erythropoiesis, eliminate hyperhomocysteinemia, and prevent folate-dependent fetal malformations.

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About the authors

Olga A. Gromova

Institute of Pharmacoinformatics, Federal Research Center "Computer Science and Control", Russian Academy of Sciences

Email: unesco.gromova@gmail.com
Dr. Med. Sci., Professor, Science №ad of the Institute of Pharmacoinformatics, Leading Researcher at the Department of Intellectual Systems

Ivan Yu. Torshin

Institute of Pharmacoinformatics, Federal Research Center "Computer Science and Control", Russian Academy of Sciences

PhD in Applied Mathematics, Institute of Pharmacoinformatics, Senior Researcher at the Department of Intellectual Systems

Nana K. Tetruashvili

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_tetruashvili@oparina4.ru
Dr. Med. Sci., Head of the 2nd Obstetrics Department of Pathology of Pregnancy

Stanislav V. Pavlovich

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: s_pavlovich@oparina4.ru
Ph.D., Academic Secretary; Professor, Department of Obstetrics, Gynecology, Perinatology and Reproductology

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