The 2019 novel coronavirus infection and pregnancy: What do we know?


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Abstract

The COVID-19 pandemic resulting from the emergence of the SARS-CoV-2 virus remains a serious global health problem. An analysis has been made of the available modern foreign and Russian literature on topical issues of the 2019 novel coronavirus infection during pregnancy. Despite the tsunami of published information, many issues remain disputable and controversial and require further study. To date, little is known about the impact of the 2019 novel coronavirus infection on pregnancy. This review considers the physiological changes during pregnancy, which make pregnant women vulnerable to contamination and severe infection, as well as the possibility of intrauterine transmission, lactation during COVID-19, and specific preventive measures. Conclusion: Understanding that pregnant women are a vulnerable population at high risk for severe COVID-19 infection is essential to improve obstetric care during a pandemic. Medical personnel should conduct educational conversations with pregnant women and/or puerperas about the importance of adhering to non-specific prevention and vaccination measures to reduce adverse obstetric and neonatal outcomes.

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About the authors

Uliana L. Petrova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: u_petrova@oparina4.ru
PhD student

Roman G. Shmakov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: r_shmakov@oparina4.ru
Dr. Med. Sci, Professor of the Russian Academy of Sciences, Head Specialist in Obstetrics of Ministry of Healthcare of Russia, Director of the Institute of Obstetrics

References

  1. Никифоров В.В., Суранова Т.Г., Чернобровкина Т.Я., Янковская Я.Д., Бурова С.В. Новая коронавирусная инфекция (COVID-19): клинико-эпидемиологические аспекты. Архивъ внутренней медицины. 2020; 10(2): 87-93.
  2. Subbaraman N. Pregnancy and COVID: what the data say. Nature. 2021; 7849(591): 193-5. https://dx.doi.org/10.1038/d41586-021-00578-y.
  3. Papapanou M., Papaioannou M., Petta A., Routsi E., Farmaki M., Vlahos N., Siristatidis C. Maternal and neonatal characteristics and outcomes of COVID-19 in pregnancy: an overview of systematic reviews. Int. J. Environ. Res. Public Health. 2021; 18(2): 596. https://dx.doi.org/10.3390/ijerph18020596.
  4. Silasi M., Cardenas I., Kwon J.Y., Racicot K., Aldo P., Mor G. Viral infections during pregnancy. Am. J. Reprod. Immunol. 2015; 73(3): 199213. https://dx.doi.org/10.1111/aji.12355.
  5. Meijer W.J., van Noortwijk A.G., Bruinse H.W., Wensing A.M. Influenza virus infection in pregnancy: a review. Acta Obstet. Gynecol. Scand. 2015; 94(8): 797819. https://dx.doi.org/10.1111/aogs.12680.
  6. Babarinsa I.A., Okunoye G.O., Odukoya O. Severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV) infections in pregnancy - An overview. Eur. J. Obstet. Gynecol. Reprod. Biol. 2021; 263: 171-5. https://dx.doi.org/10.1016/j.ejogrb.2021.06.020.
  7. Nana M., Nelson-Piercy C. COVID-19 in pregnancy. Clin. Med. (Lond). 2021; 21(5): e446-50. https://dx.doi.org/10.7861/clinmed.2021-0503.
  8. Лязгиян К.С. Клинико-иммунологические особеннности новой коронавирусной инфекции SARS-COV-2 у беременных женщин (обзор литературы). Бюллетень физиологии и патологии дыхания. 2021; 80: 91-9.
  9. Савельева Г.М., Сухих Г.Т., Серов В.Н., Радзинский В.Е., ред. Акушерство. Национальное руководство. 2-е изд. М.: ГЭОТАР-Медиа; 2018.
  10. Nowakowski F., Krajewska K., Klimek K., Wierzba W., Jakimiuk A.J. COVID-19 during pregnancy one year on-what lessons did we learn? Ginekol. Pol. 2021; 92(5): 383-6. https://dx.doi.org/10.5603/GP.a2021.0095.
  11. Papageorghiou A.T., Deruelle P., Gunier R.B., Rauch S., Garcia-May P.K., Mhatre M. et al. Preeclampsia and COVID-19: results from the INTERCOVID prospective longitudinal study. Am. J. Obstet. Gynecol. 2021; 225(3): 289.e1-289. e17. https://dx.doi.org/10.1016/j.ajog.2021.05.014.
  12. Hapshy V., Aziz D., Kahar P., Khanna D., Johnson K.E., Parmar M.S. COVID-19 and pregnancy: risk, symptoms, diagnosis, and treatment. SN Compr. Clin. Med. 2021 Apr 21:1-7. https://dx.doi.org/10.1007/s42399-021-00915-2.
  13. RCOG. Royal College of Obstetricians & Gynaecologists. Coronavirus (COVID-19) infection in pregnancy. Version 14: Published Wednesday 25 August 2021. Available at: https://www.rcog.org.uk/en/guidelines-research-services/ guidelines/coronavirus-pregnancy/
  14. Lassi Z.S., Ana A., Das J.K., Salam R.A., Padhani Z.A., Irfan O., Bhutta Z.A. A systematic review and meta-analysis of data on pregnant women with confirmed COVID-19: Clinical presentation, and pregnancy and perinatal outcomes based on COVID-19 severity. J. Glob. Health. 2021; 11: 05018. https://dx.doi.org/10.7189/jogh.11.05018.
  15. Parums D.V. Maternal SARS-CoV-2 infection and pregnancy outcomes from current global study data. Med. Sci. Monit. 2021; 27: e933831-1. https://dx.doi.org/10.12659/MSM.933831.
  16. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/ coronavirus-disease-answers?query=pregnancy+and+covid&referrerPageUr l=https%3A%2F%2Fwww.who.int%2Femergencies%2Fdiseases%2Fnovelcoronavirus-2019%2Fcoronavirus-disease-answers
  17. Chen H., Guo J., Wang C., Luo F., Yu X., Zhang W. et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. lancet. 2020; 395(10226): 809-15. https://dx.doi.org/10.1016/S0140-6736(20)30360-3.
  18. Peng Z., Wang J., Mo Y., Duan W., Xiang G., Yi M., Bao L., Shi Y. Unlikely SARS-CoV-2 vertical transmission from mother to child: a case report. J. Infect. Public Health. 2020; 13(5): 818-20. https://dx.doi.org/10.1016/j.jiph.2020.04.004.
  19. Schwartz D.A. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes. Arch. Pathol. Lab. Med. 2020; 144(7): 799-805. https://dx.doi.org/10.5858/arpa.2020-0901-SA.
  20. Zeng H., Xu C., Fan J., Tang Y., Deng Q., Zhang W., Long X. Antibodies in infants born to mothers with COVID-19 pneumonia. JAMA. 2020; 323(18): 1848-9. https://dx.doi.org/10.1001/jama.2020.4861.
  21. Shah P.S., Diambomba Y., Acharya G., Morris S.K., Bitnun A. Classification system and case definition for SARS-CoV-2 infection in pregnant women, fetuses, and neonates. Acta Obstet. Gynecol. Scand. 2020; 99(5): 565-8.
  22. Fan C., Lei D., Fang C., Li C., Wang M., Liu Y. et al. Perinatal transmission of COVID-19 associated SARS-CoV-2: should we worry? Clin. Infect. Dis. 2021; 72(5): 862-4. https://dx.doi.org/10.1093/cid/ciaa226.
  23. Yu N., Li W., Kang Q., Xiong Z., Wang S., Lin X. et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect. Dis. 2020; 20(5): 559-64. https://dx.doi.org/10.1016/S1473-3099(20)30176-6.
  24. Wang X., Zhou Z., Zhang J., Zhu F., Tang Y., Shen X. A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery. Clin. Infect. Dis. 2020; 71(15): 844-6. https://dx.doi.org/10.1093/cid/ciaa200.
  25. Buonsenso D., Costa S., Sanguinetti M., Cattani P., Posteraro B., Marchetti S. et al. Neonatal late onset infection with severe acute respiratory syndrome coronavirus 2. Am. J. Perinatol. 2020; 37(8): 869-72. https://dx.doi.org/10.1055/s-0040-1710541.
  26. Zamaniyan M., Ebadi A., Aghajanpoor S., Rahmani Z., Haghshenas M., Azizi S. Preterm delivery in pregnant woman with critical COVID-19 pneumonia and vertical transmission. Prenat. Diagn. 2020; 40(13): 1759-61. https://dx.doi.org/10.1002/pd.5713.
  27. Kirtsman M., Diambomba Y., Poutanen S.M., Malinowski A.K., Vlachodimitropoulou E., Parks W.T. et al. Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection. CMAJ. 2020; 192(24): 647-50. https://dx.doi.org/10.1503/cmaj.200821.
  28. Sukhikh G., Petrova U., Prikhodko A., Starodubtseva N., Chingin K., Chen H., Bugrova A., Kononikhin A., Bourmenskaya O., Brzhozovskiy A., Polushkina E., Kulikova G., Shchegolev A., Trofimov D., Frankevich V., Nikolaev E., Shmakov R. Vertical transmission of SARS-CoV-2 in second trimester associated with severe neonatal pathology. Viruses. 2021; 13(3): 447. https://dx.doi.org/10.3390/v13030447.
  29. Qiu L., Liu X., Xiao M., Xie J., Cao W., Liu Z. et al. SARS-CoV-2 is not detectable in the vaginal fluid of women with severe COVID-19 infection. Clin. Infecti. Dis. 2020; 71(15): 813-7. https://dx.doi.org/10.1093/cid/ciaa375.
  30. Wu Y., Liu C., Dong L., Zhang C., Chen Y., Liu J. et al. Coronavirus disease 2019 among pregnant Chinese women: case series data on the safety of vaginal birth and breastfeeding. BJOG. 2020; 127(9): 1109-15. https://dx.doi.org/10.1111/1471-0528.16276.
  31. Elshafeey F., Magdi R., Hindi N., Elshebiny M., Farrag N., Mahdy S. et al. A systematic scoping review of COVID-19 during pregnancy and childbirth. Int. J. Gynecol. Obstet. 2020;150(1): 47-52. https://dx.doi.ois/10.1002/ijgo.13182.
  32. Saadaoui M., Kumar M., Al Khodor S. COVID-19 Infection during pregnancy: risk of vertical transmission, fetal, and neonatal outcomes. J. Pers. Med. 2021; 11(6): 483. https://dx.doi.org/10.3390/jpm11060483.
  33. Raschetti R., Vivanti A.J., Vauloup-Fellous C., Loi B., Benachi A., De Luca D. Synthesis and systematic review of reported neonatal SARS-CoV-2 infections. Nat. Commun. 2020; 11(1): 5164. https://dx.doi.org/10.1038/s41467-020-18982-9.
  34. Song D., Prahl M., Gaw S.L., Narasimhan S., Rai D., Huang A. et al. Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: Prospective cohort study. medRxiv. 2021; 2021.05.01.21255871. https://dx.doi.org/10.1101/2021.05.01.21255871. Preprint.
  35. Stuebe A. The risks of not breastfeeding for mothers and infants. Rev. Obstet. Gynecol. 2009; 2(4): 222-31.
  36. Smith E.R., Locks L.M., Manji K.P., McDonald C.M., Kupka R. et al. Delayed breastfeeding initiation is associated with infant morbidity. J. Pediatr. 2017; 191: 57-62e.2. https://dx.doi.org/10.1016/j.jpeds.2017.08.069.
  37. Singh A.P., Kumar V.H.S., Panda S. Supporting breastfeeding in 2021 and beyond-lessons from the pandemic. Pediatr. Rep. 2021 ;13(2): 289-301. https://dx.doi.org/10.3390/pediatric13020037.
  38. Chen H., Guo J., Wang C., Luo F., Yu X., Zhang W. et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. lancet. 2020; 395(10226): 809-15. https://dx.doi.org/10.1016/S0140-6736(20)30360-3.
  39. Babata K.L., Yeo K.T., Chan C.S., Mazzarella K., Adhikari E.H., Kong J.Y., Hascoet J.M., Brion L.P. Feeding strategies to prevent neonatal SARS-CoV-2 infection in term or late preterm babies born to mothers with confirmed COVID-19. Cochrane Database Syst. Rev. 2020(8). https://dx.doi.org/10.1002/14651858.CD013691.
  40. Tam P.C.K., Ly K.M., Kernich M.L., Spurrier N., Lawrence D., Gordon D.L., Tucker E.C. Detectable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human breast milk of a mildly symptomatic patient with coronavirus disease 2019 (COVID-19). et al. Clin. Infect. Dis. 2021; 72(1): 128-30. https://dx.doi.org/10.1093/cid/ciaa673.
  41. Bastug A., Hanifehnezhad A., Tayman C., Ozkul A., Ozbay O., Kazancioglu S., Bodur H. Virolactia in an asymptomatic mother with COVID-19. Breastfeed. Med. 2020; 15(8): 488-91. https://dx.doi.org/10.1089/bfm.2020.0161.
  42. Flannery D.D., Puopolo K.M. Perinatal COVID-19: guideline development, implementation, and challenges. Curr. Opin. Pediatr. 2021; 33(2): 188-94. https://dx.doi.org/10.1097/MOP.0000000000000997.
  43. https://www.who.int/news-room/commentaries/detail/breastfeeding-and-covid-19
  44. Pace R.M., Williams J.E., Jarvinen K.M., Belfort M.B., Pace CD.W., Lackey K.A. et al. Characterization of SARS-CoV-2 RNA, antibodies, and neutralizing capacity in milk produced by women with COVID-19. mBio. 2021; 12(1): e03192-20. https://dx.doi.org/10.1128/mBio.03192-20.
  45. RANZCOG, COVID-19 vaccination in pregnant and breastfeeding women. Updated Wednesday 10 March 2021. Available at: https://ranzcog.edu.au/statements-guidelines/covid-19-statement/covid-19-vaccination-information
  46. Сухих Г.Т., Долгушина Н.В., Шмаков Р.Г., Климов В.А., Яроцкая Е.Л., Петрова У.Л. Исходы беременности пациенток, вакцинированных от COVID-19 во время беременности: предварительные данные. Акушерство и гинекология. 2021; 11: 5-8. [Sukhikh G.T., Dolgushina N.V., Shmakov R.G., Klimov V.A., Yarotskaya E.L., Petrova U.L. Pregnancy outcomes in patients vaccinated against COVID-19 during pregnancy: preliminary data. Akusherstvo i ginekologiya/ Obstetrics and Gynecology. 2021; 11: 5-8. (in Russian)]. https://dx.doi.org/10.18565/aig.2021.11.5-8.
  47. Министерство здравоохранения Российской Федерации. Организация оказания медицинской помощи беременным, роженицам, родильницам и новорожденным при новой коронавирусной инфекции COVID-19. Методические рекомендации. Версия 5 от 11.2021. 137c.
  48. Shimabukuro T.T., Kim S.Y., Myers T.R., Moro P.L., Oduyebo T., Panagiotakopoulos L. et al. Preliminary findings of mRNA Covid-19 vaccine safety in pregnant persons. N. Engl. J. Med. 2021; 384(24): 2273-82. https://dx.doi.org/10.1056/NEJMoa2104983.
  49. Gray K.J., Bordt E.A., Atyeo C., Deriso E., Akinwunmi B., Young N. et al. Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study. Am. J. Obstet. Gynecol. 2021; 225(3): 303.e1-303.e17. https://dx.doi.org/10.1016/j.ajog.2021.03.023.
  50. Nunes M.C., Aqil A.R., Omer S.B., Madhi S.A. The effects of influenza vaccination during pregnancy on birth outcomes: a systematic review and metaanalysis. Am. J. Perinatol. 2016; 33(11): 1104-14. https://dx.doi.org/10.1055/s-0036-1586101.
  51. Cottin J., Benevent J., Khettar S., Lacroix I. COVID-19 vaccines and pregnancy: What do we know? Therapie. 2021; 76(4): 373-4. https://dx.doi.org/10.1016/j.therap.2021.05.011.

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