The effectiveness of local cytokine therapy for chronic endometritis in patients with infertility


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Abstract

Objective: To evaluate the effectiveness of the complex of natural antimicrobial peptides and cytokines (preparation Superlymph, rectal suppositories) in the complex treatment of chronic endometritis (CE) in infertile patients. Materials and methods: This was a prospective (n=64) randomized, placebo-controlled, blinded study on the effectiveness of the complex of natural antimicrobial peptides and cytokines (Superlymph) in the complex treatment of CE in infertile patients aged 28 to 37 years (mean age was 31.88±2.65 years). Endometrial microbiota was studied. After screening and randomization, patients were categorized into the main group (n=32) and the control group (n=32). All patients received doxycycline monohydrate treatment. Additionally, patients of the main group received two courses of Superlymph with an interval of three weeks. Before and after the treatment, the microflora of the uterine cavity was evaluated and immunohistochemical examination of endometrial biopsy samples was performed. Results: After the analysis of microbiology data, it was found that the addition of local cytokine therapy contributes to the elimination of 84.04% of identified microorganisms from the uterine cavity, but in the control group this indicator was 59.13% (x2=13.075, p<0.001). There was also a statistically significant decrease in the severity of CE in the main group (x2=10.563, p=0.002). Conclusion: Adjuvant cytokine therapy in the combination treatment of CE increases a rate of elimination of microbial agents from the uterine cavity and significantly reduces the severity of CE.

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About the authors

Natalya I. Tapilskaya

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproduction; Saint Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation

Email: tapnatalia@yandex.ru
MD, PhD, DSci (Medicine), Professor, Leading researcher at the Department of Reproduction; Professor of the Department of Obstetrics and Gynecology

Gulrukhsor Kh. Tolibova

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproduction; North-Western State Medical University named after I.I. Mechnikov, Ministry of Health of the Russian Federation

Email: gulyatonbova@yandex.ru
MD, PhD, DSci (Medicine), Head of the Department of Pathomorphology, Leading researcher; Associate professor, S.N. Davydov Department of Obstetrics and Gynecology

Alevtina M. Savicheva

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproduction; Saint Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation

Email: savitcheva@mail.ru
MD, PhD, Professor, Head of the Department of Medical Microbiology; Head of the Department of Clinical Laboratory Diagnostics

A. A Kopylova

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproduction

Ruslan I. Glushakov

S.M. Kirov Military Medical Academy, Ministry of Defense of Russia; St. Petersburg State University

Email: glushakovruslan@gmail.com
MD, PhD, DSci (Medicine), Head of the Department (medical and biological research) of the Research Center; Associate professor of the Department of Pharmacology, Medical Faculty

Olga V. Budilovskaya

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproduction; Saint Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation

Email: o.budilovskaya@gmail.com
Researcher at the Department of Medical Microbiology; Assistant of the Department of Clinical Laboratory Diagnostics

Anna A. Krysanova

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproduction; Saint Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation

Email: krusanova.anna@mail.ru
Researcher at the Department of Medical Microbiology

Anton G. Gorskii

North-Western State Medical University named after I.I. Mechnikov, Ministry of Health of the Russian Federation

Email: antong9988@mailюru
6th year student of the Medical Faculty

Alexander M. Gzgzyan

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproduction; St. Petersburg State University

Email: iagmail@ott.ru
MD, PhD, DSci (Medicine), Head of the Department of Reproduction; Professor of the Department of Obstetrics, Gynecology and Reproduction, Medical Faculty

Igor Yu. Kogan

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproduction; St. Petersburg State University

Email: ikogan@mail.ru
MD, PhD, DSci (Medicine), Professor, Corresponding Member of RAS, Director; Professor of the Department of Obstetrics, Gynecology and Reproduction, Medical Faculty

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