The current state of the problem and a clinical observation of therapy for obstetric sepsis caused by ESKAPE pathogens


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Abstract

Background: According to the World Health Organization (WHO), sepsis is one of the three main causes of maternal death worldwide. The typical causative agents of sepsis in obstetrics remain sensitive to most antibacterial drugs. But, despite this, there is a steady increase in antibiotic-resistant strains of microorganisms in the population and a rise in severe cases of obstetric sepsis refractory to treatment. Case report: The authors describe a case in which, due to routing errors in the postpartum period, a female patient was infected with multidrug-resistant (MDR) microorganisms belonging to the ESKAPE pathogen group and they also provide an overview of the current procedures for overcoming antibacterial resistance. Conclusion: The systematic, multidisciplinary approach to treating sepsis in obstetrics, the widespread introduction of efferent procedures to prevent and treat multiple organ dysfunction, the close adherence to the rules of asepsis and antisepsis in managing these patients, the routing obstetric patients to specialized level III obstetric hospitals will decline the number of cases of near-miss and maternal mortality from obstetric sepsis.

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About the authors

Alexander V. Belov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_bebv@oparina4.ru
PhD, Associate Professor at the Department of Anesthesiology and Resuscitation

Aleksey V. Pyregov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_pyregov@oparina4.ru
Dr. Med. Sci., Associate Professor, Director of the Institute of Anesthesiology-Resuscitation and Transfusiology

Pavel V. Troshin

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: p_troshin@oparina4.ru
Assistant of the Department of Anesthesiology and Resuscitation

Tatyana V. Priputnevich

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: t_pnputnevich@oparina4.ru
Dr. Med. Sci., Director of the Institute of Microbiology, Antimicrobial Therapy and Epidemiology of Clinical Epidemiology

Fedor A. Kosinov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: f_kosinov@oparina4.ru
Researcher, Institute of Anesthesiology-Resuscitation and Transfusiology

Oleg V. Rogachevsky

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: o_rogachevskiy@oparina4.ru
Dr. Med. Sci., Professor, Head of the Department of Extracorporeal Methods of Treatment and Detoxification, Professor at the Department of Anesthesiology and Resuscitation

Natalia E. Shabanova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_shabanova@oparina4.ru
PhD, Researcher in the Unit of Clinical Pharmacology, the Institute of Microbiology, Antimicrobial Therapy and Epidemiology of Clinical Epidemiology

Vladimir D. Chuprynin

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_nikolaeva@oparina4.ru
Ph.D., Head of the Surgery Department

Anastasia V. Nikolaeva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

PhD, Chief Physician

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