The content of different forms of E-cadherin in blood plasma and placental tissue in preeclampsia

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Abstract

Objective: To determine the content of the adhesion molecule E-cadherin in the plasma and placenta of women with preeclampsia (PE) and assess its involvement in the development of PE.

Materials and methods: This study included 55 pregnant women. Thirty-five of them had pregnancies complicated by PE (Group I), and 20 had uncomplicated pregnancies (Group II, control). Blood plasma levels of the soluble form of E-cadherin were determined using enzyme immunoassay. Placental E-cadherin expression was studied by the Western blot method.

Results: The plasma soluble form of E-cadherin was higher in patients with PE than in controls, 8.0 ng/ml and 3.87 ng/ml, respectively (p<0.001). Placental tissue analysis showed a significantly higher content of the soluble form of E-cadherin in PE.

Conclusion: The increased level of the soluble form of E-cadherin in the plasma and placental tissue in PE reflects the abnormal proliferation and differentiation of trophoblasts, which is typical of this pathology.

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About the authors

Artemiy P. Shelekhin

I.M. Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University)

Author for correspondence.
Email: dr.shelekhin@gmail.com
ORCID iD: 0000-0002-7682-1329

Postgraduate Student

Russian Federation, Moscow

Oleg R. Baev

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation; I.M. Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University)

Email: o_baev@oparina4.ru
ORCID iD: 0000-0001-8572-1971

Dr. Med. Sci., Professor, Head of the 1st Maternity Department, Academician V.I. Kulakov NMRС for OG&P, Ministry of Health of Russia

Russian Federation, Moscow; Moscow

Alsu A. Sadekova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: sialsad@gmail.com
ORCID iD: 0000-0003-4726-7477

PhD, Senior Researcher at the Cytology Laboratory

Russian Federation, Moscow

Diana N. Kokoeva

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: Dikokoeva@mail.ru

Junior Researcher at the Cytology Laboratory

Russian Federation, Moscow

Alexey M. Krasnyi

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: a_krasnyi@oparina4.ru
ORCID iD: 0000-0001-7883-2702

PhD, Head of the Cytology Laboratory

Russian Federation, Moscow

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