For the first time in Russia: delivery of twins in patient with premature ovarian insufficiency after a onestage surgical procedure for activation of ovarian function


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Abstract

Premature ovarian insufficiency (POI) is a multifactorial disease with a significant contribution of genetic factors; one of the leading socially significant complaints in this disease is persistent infertility with a high resistance to standard treatment methods. The method for activating follicular growth, which was first described by K. Kawamura, A. Hsueh and co-authors, turned out to be effective and it was confirmed clinically and by molecular genetic research data. Currently, it has been used in various modifications in more than 6 countries around the world. In Russia, the first operation based on surgical activation of ovarian function was performed by academician of the Russian Academy of Sciences L.V. Adamyan on March 06, 2019. For the first time in Russia, a 32-year-old patient suffering from premature ovarian insufficiency with dichorionic diamniotic twins underwent planned operative delivery by caesarean section at 37 weeks and 4 days of gestation. The operation was performed at the V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia, on October 01, 2020. The patient became pregnant spontaneously 1.5 months after undergoing surgical treatment aimed at restoring reproductive potential. A one-stage surgical procedure for activation of ovarian function was performed by academician L.V. Adamyan on December 13, 2019. Conclusion. This clinical case of a spontaneous pregnancy and delivery in the patient with POI demonstrates that this operation is appropriate to be performed in patients with a noticeable decrease in the ovarian reserve, and it can be considered as an alternative to oocyte donation.

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About the authors

Leyla V. Adamyan

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation

Email: adamyanleila@gmail.com
Academician of RAS, MD, PhD, Professor RAS, Honored Master of Science of the Russian Federation, Head Specialist in Obstetrics and Gynecology of Ministry of Health of Russia, Vice-Director

Victoria O. Dementyeva

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation

Email: victoriadementyeva93@gmail.com
PhD student

Alexanda V. Asaturova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation

Email: a_asaturova@oparina4.ru
PhD, pathologist, Head of the Pathomorphological Department

Assia A. Stepanian

Academia of Women's Health and Endoscopic Surgery, Atlanta

Email: astep@migsurgery.com

Veronika Yu. Smolnikova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation

Email: veronika.smolnikova@mail.ru
PhD, Leading Researcher in the Department of Assistive Technologies in the Treatment of Infertility named after B.V. Leonov

Alek S. Arakelyan

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation

Email: a_arakelyan@oparina4.ru
Ph.D., Senior Researcher of the Gynecological Department

Aleksandr I. Gus

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation

Email: a_gus@oparina4.ru
PhD, professor, Head of the Department of Ultrasound and Functional Diagnostics

Anastasia V. Nikolaeva

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation

Email: a_nikolaeva@oparina4.ru
PhD, Chief Physician

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