Fetal sex in the development of gestational diabetes mellitus and endothelial dysfunction


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. To evaluate the effect of the fetal sex on the levels of certain hormones, neurotransmitters, vasoconstrictors, as well as on the pro- and contrinsular factors, and to reveal the role of the fetal sex in the genesis of gestational diabetes mellitus and the development of endothelial dysfunction. Materials and methods. The study included 1101 pregnant women: 517 women with gestational diabetes mellitus and 584 women with normal gestation. Certain metabolism-associated hormones, neurotransmttters, vasoconstrictors, pro- and contrinsular factors were assessed in blood serum of these women with ELISA test. Results. Male fetus was found to mediate the greatest changes in the levels of prolactin, endothelin-1, angiotensin II, epinephrine, glycosylation-end product receptors, insulin-like growth factor-1 and its transport proteins which contribute to metabolic disorders and the development of endothelial dysfunction in pregnant women. Conclusion. The fetal sex is an important factor affecting the carbohydrates metabolism and the nature of the hormonal response of the mother’s organism during gestational changes. The fetal sex is a trigger in the development of gestational diabetes and endothelial dysfunction, which cause obstetric complications.

Full Text

Restricted Access

About the authors

Tatyana L. Botasheva

Rostov State Medical University, Ministry of Health of Russia

Email: t_botasheva@mail.ru
MD, PhD, Professor, chief researcher, Department of Biomedical Problems in Obstetrics, Gynecology and Pediatrics

Natalia V. Palieva

Rostov State Medical University, Ministry of Health of Russia

Email: nat-palieva@yandex.ru
MD, PhD, chief research officer at the Obstetrics and Gynecology Department

Anna V. Khloponina

Rostov State Medical University, Ministry of Health of Russia

Email: annakhloponina@yandex.ru
PhD, senior research fellow at the Obstetrics and Gynecology Department

Valentina V. Vasiljeva

Rostov State Medical University, Ministry of Health of Russia

Email: v.vasiljeva1965@mail.ru
Doctor of Biology, Associate Professor, leading researcher, Department of Biomedical Problems in Obstetrics, Gynecology and Pediatrics

Elena V. Zheleznyakova

Rostov State Medical University, Ministry of Health of Russia

Email: elena.Gel.1961@yandex.ru
PhD, research associate, Department of Biomedical Problems in Obstetrics, Gynecology and Pediatrics

Oleg P. Zavodnov

Rostov State Medical University, Ministry of Health of Russia

Email: ozz2007@mail.ru
PhD in Biology, researcher, Department of Biomedical Problems in Obstetrics, Gynecology and Pediatrics

Ekaterina B. Gudz

Rostov State Medical University, Ministry of Health of Russia

Email: ya-kate4ka@yandex.ru
PhD, research fellow at the Obstetrics and Gynecology Department

References

  1. Капустин Р.В., Аржанова О.Н., Беспалова О.Н., Пакин В.С., Айламазян Э.К. Патологическая прибавка веса как фактор развития гестационного сахарного диабета: систематический обзор и мета-анализ. Акушерство и гинекология. 2016; 5: 12-9
  2. Линде В.А., Палиева Н.В., Боташева Т.Л., Авруцкая В.В., Дударева М.В. Роль про- и контринсулярных факторов в формировании акушерской патологии. Акушерство и гинекология. 2017; 2: 32-8. [Linde V.A., Palieva N.V., Botasheva T.L., Avrutskaya V.V., Dudareva M.V. Role of pro-and contra-insular factors in the formation of obstetric pathology. Akusherstvo i Ginekologiya / Obstetrics and Gynecology. 2017; 2: 32-8. (in Russian)] https:// dx.doi.org/10.18565/aig.2017.2.32-8.
  3. Радзинский В.Е., Боташева Т.Л., Котайш Г.А. ред. Ожирение. Диабет. Беременность. Версии и контраверсии. Клинические практики. Перспективы. Радзинский В.Е., Боташева Т.Л, Папышева О.В., Волкова Н.И., Палиева Н.В. и др. Москва: ГЭОТАР-Медиа. 2020; 528 с. [Radzinsky V.E., Botasheva T.L., Kotaysh G.A. ed. Obesity. Diabetes. Pregnancy. Versions and contraverses. Clinical practices. Prospects. Radzinsky V.E., Botasheva T.L., Papysheva O.V., Volkova N.I., Palieva N.V. et al. Moscow: GEOTAR-Media. 2020; 528 р. (in Russian)].
  4. Палиева Н.В., Боташева Т.Л., Линде В.А., Авруцкая В.В., Железнякова Е.В. Особенности некоторых вазоактивных гормонов и сосудистых факторов у женщин с метаболическим синдромом и их влияние на формирование акушерских осложнений. Акушерство и гинекология. 2017; 6: 48-54. [Palieva N.V., Botasheva T.L., Linde V.A., Avrutskaya V.V., Zheleznyakova E.V. Features of some vasoactive hormones and vascular factors in women with metabolic syndrome and their influence on the development formation of obstetric complications. Akusherstvo i ginekologija / Obstetrics and gynecology. 2017; 6: 48-54. (in Russian)]. https://dx.doi.org/10.18565/ aig.2017.6.48-54.
  5. Гармашева Н.Л., Константинова Н.Н. Патофизиологические основы охраны внутриутробного развития человека. Л.: Медицина. 1985; 159 с. [Garmasheva N.L., Konstantinova N.N. Pathophysiological basis for the protection of intrauterine development. Leningrad: Medicine. 1985; 159 р. (in Russian)].
  6. Боташева Т.Л., Васильева В.В., Хлопонина А.В., Заводнов О.П., Каушанская Л.В., Железнякова Е.В. Сезонная периодичность мелатонинового обмена и гормонального статуса беременных в зависимости от пола плода. Медицинский вестник Юга России. 2018; 9(3): 70-6. [Botasheva T.L., Khloponina A.V., Vasil’eva V.V., Zavodnov O.P., Kaushanskaya L.V., Zheleznyakova E.V. Seasonal periodicity of melatonin exchange and hormonal status of pregnant women in dependence on fetus sex. Medicinskij vestnik Yuga Rossii / Medical Herald of the South of Russia. 2018; 9(3): 70-6. (in Russian)]. https://dx.doi.org/10.21886/2219-8075-2018-9-3-70-76.
  7. Боташева Т.Л., Радзинский В.Е., Хлопонина А.В., Васильева В.В., Заводнов О.П., Железнякова Е.В. и др. Пол плода в экспрессии ангио-генных факторов и поддержании цитокинового баланса в материнском организме при физиологической беременности и плацентарной недостаточности. Медицинский вестник Северного Кавказа. 2019; 14(2): 325-9. [Botasheva T.L., Radzinsky V.E., Khloponina A.V., Vasil’eva V.V., Zavodnov O.P., Zheleznyakova E.V. et al. Role of fetus sex in expression of angiogenic factors and supporting of citokine balance in maternal organism in physiological pregnancy and in placentary insufficiency. Medicinskij vestnik Severnogo Kavkaza / Medical Bulletin of the North Caucasus. 2019; 14(2): 3259. (in Russian)]. https://doi.org/10.14300/mnnc.2019.14079.
  8. Larsen S.O., Wojdemann K.R., Shalmi A.C., Sundberg K., Christiansen M., Tabor A. Gender impact on first trimester markers in Down syndrome screening. PrenatDiagn. 2002; 22: 1207-8. https://doi.org/10.1002/pd.493.
  9. Knippel A.J. Role of fetal sex in amniotic fluid alphafetoprotein screening. Prenatal Diagnosis. 2002; 22(10): 941-5. https://doi.org/10.1002/pd.408
  10. DiRenzo G.C., Rosati A., Sarti R.D., Cruciani L., Cutuli A.M. Does fetal sex affect pregnancy outcome? Gend Med. 2007; l 4(1): 19-30.
  11. Gonzalez T.L., Sun T., Koeppel A.F., Lee B., Wang E.T., Farber C.R. et al. Sex differences in the late first trimester human placenta transcriptome. Biology of Sex Differences. 2018; 9(1): 4. https://doi.org/10.1186/s13293-018-0165-y
  12. Wax J.R., Cartin A., Pinette M.G., Blackstone J. Does the frequency of soft sonographic aneuploidy markers vary by fetal sex? J. Ultrasound Med. 2005; 24(8): 1059-1063. http://dx.doi.org/10.7863/jum.2005.24.8.1059
  13. Del Mar Melero-Montes М., Jick Н. Hyperemesis Gravidarum and the Sex of the Offspring. Epidemiology. 2000; 12(1): 123-4.
  14. Sheiner E., Levy A., Katz M., Hershkovitz R., Leron E., Mazor M. Gender does matter in perinatal medicine. Fetal Diagn Ther. 2004; 19(4): 366-9. http:// dx.doi.org/10.1159/000077967
  15. Палиева Н.В., Боташева Т.Л., Радзинский В.Е., Черноситов А.В. Особенности метаболизма при физиологической и осложненной беременности с позиций стереофункциональной и хронофизиологической организации системы «мать-плацента-плод»: монография. Ростов н/Д: РГЭУ (РИНХ). 2016; 178 с. [Palieva N.V., Botasheva T.L., Radzinsky V.E., Chernositov A.V. Features of metabolism in physiological and complicated pregnancies in dependence on the stereofunctional and chronophysiological organization of the mother-placenta-fetus system: monograph. Rostov-on-Don: RSEU (RINH). 2016; 178 p.].
  16. George E.M., Granger J.P. Endothelin: key mediator of hypertension in preeclampsia. Am. J. Hypertens. 2011; 24(9): 964-9.
  17. Swiderski S., Celewicz Z., Miazgowski T., Ogonowski J. Maternal endothelin-1 and cyclic guanosine monophosphate concentrations in pregnancies complicated by pregravid and gestational diabetes mellitus. Gynecol. Obstet. Invest. 2010; 69: 46-50.
  18. Lappas M., Jinks D., Shub A. , Willcox J.C., Georgiou H.M., Permezel M. Postpartum IGF-I and IGFBP-2 levels are prospectively associated with the development of type 2 diabetes in women with previous gestational diabetes mellitus. Diabetes & Metabolism. 2016; 42: 442-7.
  19. Majerczyk M., Olszanecka-Glinianowicz M., Puzianowska-Kuznicka M., Chudek J. Retinol-binding Protein 4 (RBP4) as the Causative Factor and Marker of Vascular Injury Related to Insulin Resistance. Postepy Hig Med Dosw (Online). 2016, Dec 21; 70(0): 1267-1275.
  20. Du X., Dong Y., Xiao L., Hui Liu G., Qin W., Yu H. Association between retinol-binding protein 4 concentrations and gestational diabetes mellitus (A1GDM and A2GDM) in different pregnancy and postpartum periods. Ann Transl Med. 2019, Sep; 7(18): 479. http://dx.doi.org/10.21037/atm.2019.08.45.
  21. Двойрин В.В., Клименков А.А. Методика контролируемых клинических испытаний. Москва. 2004; 143 с. [Dvoirin V.V., Klimenkov A.A. Methodology of controlled clinical trials. Moscow. 2004; 143 p. (in Russian)].
  22. Боярский А.Я., Громыко Л.Г. Общая теория статистики. М.: Московский университет. 1985; 376 с. [Boyarsky A.Ya., Gromyko L.G. General theory of statistics. Moscow: Moscow University, 1985. 376 p. (in Russian)].
  23. Mountjoy K.G. Proopiomelanocortin (POMC) neurones, POMC-derived peptides, melanocortin receptors and obesity: how understanding of this system has changed over the last decade. J. Neuroendocrinol. 2015; 27(6): 406-18. http://dx.doi.org/10.1111/jne.12285.
  24. Sternson S.M., Atasoy D. Agouti-related protein neuron circuits that regulate appetite. Neuroendocrinology. 2014; 100(2/3): 95-102. http://dx.doi. org/10.1159/000369072.
  25. Макарова Е.Н., Романова И.В., Бажан Н.М. Регуляция потребления пищи в период беременности и лактации у мышей со сниженной активностью меланокортиновой системы. Вавиловский журнал генетики и селекции. 2016; 20(2): 138-44. doi: 10.18699/VJ16.124. [Makarova E.N., Romanova I.V., Bazhan N.M. Regulation of food intake during pregnancy and lactation in mice with reduced activity of the melanocortin system. Vavilov Journal of Genetics and Breeding. 2016; 20 (2): 138-44. (in Russian)]. http://dx.doi.org/10.18699 / VJ16.124.
  26. Ling C., Billig H. PRL receptor-mediated effects in female mouse adipocytes: PRL induces suppressors of cytokine signaling expression and suppresses insulin-induced leptin production in adipocytes in vitro. Endocrinology. 2001; 142 (11): 480-90.
  27. Tuzcu A., Bahceci M., Dursun M. et al. Insulin sensitivity and hyperprolactinemia. J Endocrinol Invest. 2003; 26 (4): 341-6.
  28. Reinhold S.W, Uihlein D.C., Boger C.A., Kloiber S., Frolich K., Bergler T., Banas B., Schweda F., Kramer B.K. Renin, Endothelial NO Synthase and Endothelin Gene Expression in the 2kidney-1clip Goldblatt Model of LongTerm Renovascular Hypertension. Eur J Med Res. 2009; 14(12): 520-5. http:// dx.doi.org/10.1186/2047-783x-14-12-520.
  29. Nakamura K., Yamagishi S.I., Adachi H., Kurita Y., Takanori N., Matsui T., Imaizumi Y.T. Serum Levels of sRAGE, the Soluble Form of Receptor for Advanced Glycation End Products, Are Associated with Inflammatory Markers in Patients with Type 2 Diabetes. Mol Med. 2007, Mar-Apr; 13(3-4): 185-9. http://dx.doi.org/10.2119/2006-00090.Nakamura.
  30. Matsui T., Higashimoto Y., Nishino Y., Nakamura N., Fukami K., Yamagishi S.I., Matsui T., et al. RAGE-Aptamer Blocks the Development and Progression of Experimental Diabetic Nephropathy. Diabetes. 2017, Jun; 66(6): 1683-95. http://dx.doi.org/10.2337/db16-1281.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies