Fibrin monomer and D-dimer in infertile women undergoing assisted reproductive technology


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Abstract

Aim. To investigate the levels of f ibrin monomer and D-dimer as markers of activation of the coagulation system in infertile women undergoing assisted reproductive technology (ART). Materials and methods. The study included 68 patients, who were divided into a group of infertile women (group 1, n=36) and a control group (group 2, n=32). Fibrin monomer and D-dimer were analyzed using a latex-enhanced immunoturbidimetric assay. Results. Patients undergoing ART had increased procoagulant activity of blood, as evidenced by an increase in fibrin monomer and D-dimer concentrations (p<0.001). There was a relationship between the studied parameters and an increase in the level of β--hCG in group 1 (p<0.001); no association was found with body mass index, age, and infertility factor. Conclusion. ART is associated with an increase in the levels of fibrin monomer and D-dimer. The rise in the fibrin monomer level was more significant compared with D-dimer. Patients with endometriosis-associated infertility had a relative increase in the fibrin monomer level, which requires further investigation. An increase in the fibrin monomer level in patients with a confirmed pregnancy demonstrates an increase in the procoagulant activity of blood at early gestational ages.

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About the authors

Alina O. Godzoeva

V.A. Almazov Federal Medical Research Center, Ministry of Health of Russia

Email: godzoevaalina@mail.ru
Ph.D. Student at the Department of Obstetrics and Gynecology

Irina E. Zazerskaya

V.A. Almazov Federal Medical Research Center, Ministry of Health of Russia

Email: zazera@mail.ru
M.D., Dr.Med.Sci., Head of the Department of Obstetrics and Gynecology

Vladimir S. Vlasov

V.A. Almazov Federal Medical Research Center, Ministry of Health of Russia

Email: vlasov1989vladimir@gmail.com
Specialist at the Department of Laboratory Medicine and Genetics

Tatyana V. Vavilova

V.A. Almazov Federal Medical Research Center, Ministry of Health of Russia

Email: vtv.lab.spb@gmail.com
M.D., Dr.Med.Sci., Head of Department of Laboratory Medicine and Genetics

Inga V. Gorelova

V.A. Almazov Federal Medical Research Center, Ministry of Health of Russia

Email: ivmosyagina@gmail.com
M.D., Ph.D., Head of the Department of Reproductive technologies

Vitaly N. Kustarov

V.A. Almazov Federal Medical Research Center, Ministry of Health of Russia

Email: prof.kustarov@gmail.com
M.D., Ph.D., Dr.Med.Sci., Professor at the Department of Obstetrics and Gynecology

Tuyana V. Zhambalova

V.A. Almazov Federal Medical Research Center, Ministry of Health of Russia

Email: 2yana1@rambler.ru
Ph.D. Student at the Department of Obstetrics and Gynecology

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