Human papillomavirus genotyping results of human papillomavirus vaccinated women of reproductive age

Objective. To determine the most common types of human papillomavirus (HPV) involved in the neoplastic transformation of the cervical epithelium in HPV vaccinated women of reproductive age. Materials and methods. The study included 3 groups with 141 patients. Group 1 (HPV vaccinated) included 62 patients (average age of 31 years). This group was divided into 2 subgroups: patients vaccinated before sexual activity (n=26, 41.9%) were enrolled in subgroup 1a and women vaccinated after sexual activity (n=36, 58.06%) were in subgroup 1b. Group 2 included patients with the cytological diagnosis of high-grade squamous intraepithelial lesions (HSIL) (n=42), group 3 included patients negative for intraepithelial lesion or malignancy (NILM) (controlgroup, n=37). A comprehensive clinical and laboratory examination was carried out, including HPV typing, cytological examination. Results. Among them, 76 (53.9%) patients were HPV-positive: 100% in the HSIL group, 54% in the NILMgroup and 22.5% in the vaccinated group (38.8% in subgroup 1b and 0% in subgroup 1a). HPV vaccine types were statistically significantly less identified in group 1 (vaccinated) - 6.4%, compared to group 2 (HSIL) (29.7%) (p<0.05). In group 1 the most common type of HPV was HPV 56 (4.2%), in groups 2 and 3, HPV type 16 was the most common one with 21.9% and 4.96%, respectively. Conclusion. HPV of group 1 (carcinogenic) A9 and A7 were significantly less common in patients of group 1 compared to unvaccinated patients of groups 2 and 3.

cervical intraepithelial neoplasia, human papillomavirus, vaccination