Search for prognostic markers of the course of endometriosis

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Abstract

Endometriosis is regarded as one of the most urgent problems of modern gynecology, whereas its prevalence is about 10% (190 million females) of all reproductive-aged women worldwide. Despite the benign nature of this disease, this process has the features similar to those of malignant diseases, such as loss of cell proliferation control, a tendency for invasive growth, an elevated blood level of cancer-specific markers, and a propensity to relapse.The paper reviews the literature data by Russian and foreign authors, which have been published in the Cochrane Library, Pubmed, and eLibrary databases on the role of the following biomarkers: acetylcholine receptors, matrix metalloproteinases, paraoxonases, bradykinin receptors, and estradiol receptors, in the context of evaluating the course of endometriosis. The increasing role of this disease in the pattern of gynecological diseases, the social significance of the problem, long diagnostic periods, and treatment start since the first symptoms appear generate a need for the medical community to conduct a comprehensive study of this pathology.

Conclusion: Further in-depth study and clarification of the etiopathogenetic mechanisms of endometriosis, as well as the creation of new diagnostic models, will be able to more successfully apply and/or to combine various procedures and methods for treating this disease, developing a modern concept of epigenetic rehabilitation, and improving quality of life in these patients.

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About the authors

Sergey A. Levakov

I.M. Sechenov First Moscow State Medical University (Sechenov University) , Ministry of Health of Russia

Author for correspondence.
Email: levakov_s_a@staff.sechenov.ru

Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, N.V. Sklifosovsky Institute of Clinical Medicine

Russian Federation, Moscow

Yulia A. Pertseva

I.M. Sechenov First Moscow State Medical University (Sechenov University) , Ministry of Health of Russia

Email: yurchenko_yulya@mail.ru

postgraduate student, Department of Obstetrics and Gynecology, N.V. Sklifosovsky Institute of Clinical Medicine

Russian Federation, Moscow

Elizaveta A. Obukhova

I.M. Sechenov First Moscow State Medical University (Sechenov University) , Ministry of Health of Russia

Email: liza_obukhova@mail.ru

Assistant, Department of Obstetrics and Gynecology, N.V. Sklifosovsky Institute of Clinical Medicine

Russian Federation, Moscow

Sergey V. Paukov

I.M. Sechenov First Moscow State Medical University (Sechenov University) , Ministry of Health of Russia

Email: paukov_s_v@staff.sechenov.ru

PhD, Associate Professor, Department of Obstetrics and Gynecology, N.V. Sklifosovsky Institute of Clinical Medicine

Russian Federation, Moscow

Natalia L. Bondarenko

Clinical Hospital No. 85, Federal Biomedical Agency of Russia

Email: levakov_s_a@staff.sechenov.ru

PhD, Chief Physician

Moscow

Mikhail I. Shakhparonov

Academicans M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: shakhparonov@gmail.com
ORCID iD: 0000-0001-5965-8067

PhD in Chemistry, Leading Researcher at the Laboratory of Membrane and Bioenergetic Systems

Russian Federation, Moscow

Nadezhda V. Antipova

Academicans M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: Nadine.antipova@gmail.com

PhD, Senior Researcher at the Laboratory of Membrane and Bioenergetic Systems; Associate Professor, Department of Pharmaceutical and Toxicological Chemistry

Russian Federation, Moscow

References

  1. Adamyan L.V. Endometriosis. In.: Sukhikh G.T., Serov V.N., Prilepskaya V.N., Baranov I.I., eds. Gynecology. Pharmacotherapy without errors. Guidelines for physicians. Moscow: E-Noto; 2020: 305-17. (in Russian).
  2. Gao M., Koupil I., Sjöqvist H., Karlsson H., Lalitkumar S., Dalman C., Kosidou K. Psychiatric comorbidity among women with endometriosis: nationwide cohort study in Sweden.. Am. J. Obstet. Gynecol. 2020; 223(3): 415.e1-415.e16. https://dx.doi.org/10.1016/j.ajog.2020.02.033.
  3. Levakov S.A., Mamedova A.E.K., Azadova G.Y.K., Paukov S.V., Khomeriki T.A., Ilyina O.V. Improving the quality of diagnosis of the spread of ovarian endometriosis. Nat. Volatiles & Essent. Oils. 2021; 8(4): 1761-73.
  4. Dubrovina S.O., Berlim Yu.D., Aleksandrina A.D., Vovkochina M.A., Tsirkunova N.S., Bogunova D.Yu. Endometriosis in routine practice: analysis of clinical cases. Obstetrics and Gynecology. 2022; (6): 152-61. (in Russian). https://dx.doi.org/10.18565/aig.2022.6.152-161.
  5. Zondervan K.T., Becker C.M., Missmer S.A. Endometriosis. N. Engl. J. Med. 2020; 382(13): 1244-56. https://dx.doi.org/10.1056/NEJMra1810764.
  6. Agarwal S.K., Chapron C., Giudice L.C., Laufer M.R., Leyland N., Missmer S.A. et al. Clinical diagnosis of endometriosis: a call to action. Am. J. Obstet. Gynecol. 2019; 220(4): 354.e1-354.e12. https://dx.doi.org/10.1016/j.ajog.2018.12.039.
  7. Senina D.N., Chuprynin V.D., Buralkina N.A., Chursin V.V., Smolnova T.Yu., Davidyan L.Yu., Abosov A.S. Main criteria and risk factors for the development of recurrent endometriosis. Obstetrics and Gynecology. 2022; (10): 22-6. (in Russian). https://dx.doi.org/10.18565/aig.2022.10.22-26.
  8. Lavrukhina M.A. Determination of treatment policy for infertility in patients with ovarian endometrioid cysts. Obstetrics and Gynecology. 2022; (5): 23-9. (in Russian). https://dx.doi.org/10.18565/aig.2022.5.23-29.
  9. WHO. Female Genital Tumours. WHO Classification of Tumours, 5th ed., vol. 4, 2020. Available at: https://publications.iarc.fr/Book-And-Report-Series/Who-Classification-Of-Tumours/Female-Genital-Tumours-2020
  10. Höhn A.K., Brambs C.E., Hiller G.G.R., May D., Schmoeckel E., Horn L.-C. 2020 WHO Classification of Female Genital Tumors. Geburtshilfe Frauenheilkd. 2021; 81(10): 1145-53. https//dx.doi.org/10.1055/a-1545-4279.
  11. Davydov A.I., Mikhaleva L.M., Khabarova M.B., Chilova R.A., Lebedev V.A. Endometrioid cystadenoma – deep ovarian endometriosis. Issues of Gynecology, Obstetrics and Perinatology. 2022; 21(3): 130-7. (in Russian). https://dx.doi.org/10.20953/1726-1678-2022-3-130-137.
  12. Becker C.M., Bokor A., Heikinheimo O., Horne A., Jansen F., Kiesel L. et al; ESHRE Endometriosis Guideline Group. ESHRE guideline: endometriosis. Hum. Reprod. Open. 2022; 2022(2): hoac009. https://dx.doi.org/10.1093/hropen/hoac009.
  13. Hecht J.L., Janikova M., Choudhury R., Liu F., Canesin G., Janovicova L. et al. Labile рeme and heme oxygenase-1 maintain tumor-permissive niche for endometriosis-associated ovarian cancer. Cancers (Basel). 2022; 14(9): 2242. https://dx.doi.org/10.3390/cancers14092242.
  14. Patel B.G., Lenk E.E., Lebovic D.I., Shu Y., Yu J., Taylor R.N. Pathogenesis of endometriosis: Interaction between Endocrine and inflammatory pathways. Best Pract. Res. Clin. Obste.t Gynaecol. 2018; 50: 50-60. https://dx.doi.org/ 10.1016/j.bpobgyn.2018.01.006.
  15. Johnson N.P., Hummelshoj L., Adamson G.D., Keckstein J., Taylor H.S., Abrao M.S. et al.; World Endometriosis Society Sao Paulo Consortium. World Endometriosis Society consensus on the classification of endometriosis. Hum. Reprod. 2017; 32(2):315-24. https://dx.doi.org/10.1093/humrep/dew293.
  16. Mezhlumova N.A., Bobrov M.Yu., Adamyan L.V. Biomarkers of endometriosis: problems and possibilities of early detection of disease recurrence (a review). Russian Journal of Human Reproduction. 2018; 24(6): 139 48. (in Russian). https://dx.doi.org/ 10.17116/repro201824061139.
  17. Bulatova L.S., Solomatina A.A., Kareva E.N., Kotsyubinskaya N.A. Expression of steroid hormone receptors in the tissue of endometriomas in first-time and relapsing patients. Bulletin of RSMU. 2018; (1): 60-4. (in Russian). https://dx.doi.org/10.24075/vrgmu.2018.014.
  18. Chen Q., Qu J., Xu Y., Yu Y., Huang X., Zhou L. et al. Expressions of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in ectopic and eutopic endometrium. Zhonghua Fu Chan Ke Za Zhi. 2004; 39(12): 809-12.
  19. Krasnyi A.M., Volgina N.E., Sadekova A.A., Shchpitsyna V.S., Sukhikh G.T., Adamyan L.V., Ozernyuk N.D. Activation of α7-nicotinic acetylcholine receptors causes secretion of matrix metalloproteinases-9 in the human endometrium. Biology Bulletin. 2017; 44: 109-12. https://dx.doi.org/10.1134/S1062359017020078.
  20. Alwazzan A., Mehboob R., Gilani S.A., Mehboob R., Gilani S.A., Hassan A. et al. Immunohistochemical expression of the alpha nicotinic acetylcholine receptor 7 in the human normal, diabetic, and preeclamptic placenta and products of conception. Front. Physiol. 2020; 11: 607239. https://dx.doi.org/10.3389/fphys.2020.607239.
  21. Xu X., Cai X., Liu X., Guo S.W. Possible involvement of neuropeptide and neurotransmitter receptors in Adenomyosis. Reprod. Biol. Endocrinol. 2021; 19(1): 25. https://dx.doi.org/10.1186/s12958-021-00711-6.
  22. Meng X., Li Y., Li Q., Yang J., An M., Fu X. et al. Involvement of bradykinin and bradykinin B1 receptor in patients with endometriosis. Exp. Ther. Med. 2021; 22(5): 1240. https://dx.doi.org/10.3892/etm.2021.10675.

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