Prospects of treating infertility in women over 40 using assisted reproductive technology with autologous oocytes

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Today, childbearing in women of late reproductive age is not only a pressing clinical problem but also a social one. In couples in this age group, the pathogenesis of infertility is extremely complex, representing a combination of several factors that often require tailored treatment for individual patients.

This review presents data on the role of genetic factors and oxidative stress signaling pathways in the pathogenetic mechanisms underlying ovarian aging. The authors summarized various controlled ovarian stimulation protocols and approaches for the optimization of assisted reproductive technology in patients of late reproductive age. This article provides information about experimental studies that will expand our understanding of the prospects for treating infertility in patients of this age category.

Conclusion: The study of pathogenetic mechanisms of ovarian aging is one of the key directions for the optimization of infertility treatment in women of late reproductive age using ART with autologous oocytes and is of scientific interest for the future development of innovative therapeutic approaches for this cohort of patients.

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作者简介

Leah Khachatryan

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

编辑信件的主要联系方式.
Email: leahkhachatryan@gmail.com
ORCID iD: 0000-0003-4867-500X

postgraduate student of the Department of Obstetrics, Gynecology, Perinatology and Reproductology, Faculty of Postgraduate Professional Training of Physicians

俄罗斯联邦, Moscow

Natalya Makarova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: np_makarova@oparina4.ru

PhD, Leading Researcher at the Department of Assistive Technologies in Infertility Treatment

俄罗斯联邦, Moscow

Andrey Kalinin

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: zoaza8@mail.ru

student of the Faculty of Medicine

俄罗斯联邦, Moscow

Veronika Smolnikova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: v_smolnikova@oparina4.ru

Dr. Med. Sci., Leading Researcher, Department of Assistive Technologies in Infertility Treatment

俄罗斯联邦, Moscow

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