Correction of an iron-deficiency state in women during pregnancy

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Abstract

Objective: To estimate the level and rate of an iron deficiency state in pregnant women in the initial gestation period and to analyze the therapeutic efficacy of the use and clinical tolerability of the iron agent ferrous protein succinylate/folinic acid in the patients of this group.

Materials and methods: A total of 524 women who were registered for pregnancy in the VitroClinic were examined. All the patients underwent serum ferritin concentration determinations in addition to general clinical blood testing. During their therapy, 221 pregnant women with identified iron deficiency were divided into two groups. The study group patients (n=112) took ferrous protein succinylate in combination with folinic acid; the comparison group patients (n=109) received other agents based on inorganic iron (II) salts.

Results: According to our data, at the beginning of the gestation, iron deficiency was identified in 67.2% of the pregnant women; moreover, half of them had latent iron deficiency detectable by the ferritin concentration. The pregnant women’s use of the drug Ferlatum Fol based on a combination of ferrous protein succinylate and folinic acid demonstrated a more significant therapeutic effect; as a result of two-month intake of the drugs; the average increase in ferritin levels was 110.5%, relatively 61.0% in the women who received other iron agents, that in hemoglobin was 12.6% and 5.1% and in packed cell volume was 9.1% and 6.1%, respectively (p<0.001). Adverse reactions were detected in 7/112 (6.3%) pregnant women taking Ferlatum Fol and in 12/109 (11.1%) patients taking iron (II) salts.

Conclusion: Ferlatum Fol is highly effective in rapidly correcting hyposiderosis in the patients in the gestation period, has a high safety profile and an extremely low rate of side effects.

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About the authors

Sergey V. Khabarov

Medical Institute, Tula State University; Academy of Postgraduate Education, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of Russia; VitroClinic, IVF “Genome” Clinics Network, “Medma” Companies Group

Author for correspondence.
Email: s.v.habarov@mail.ru
ORCID iD: 0000-0002-1736-9408
SPIN-code: 1896-1300
Scopus Author ID: 57220038210
ResearcherId: ABB-2726-2021

Dr. Med. Sci., Merited Doctor of the Russian Federation, Associate Professor, Professor at the Department of Obstetrics and Gynecology; Professor at the Department of Clinical Laboratory Diagnostics and Pathological Anatomy

Russian Federation, Tula; Moscow; Moscow

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