Hormonal profile of oocyte donors during ovarian stimulation at different phases of the menstrual cycle
- Authors: Lapina V.S.1, Martazanova B.A.1, Durinyan E.R.1, Amyan T.S.1, Korolkova A.I.1, Gavisova A.A.1
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Affiliations:
- Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
- Issue: No 8 (2023)
- Pages: 96-102
- Section: Original Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/587983
- DOI: https://doi.org/10.18565/aig.2023.152
- ID: 587983
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Abstract
Objective: To compare the hormonal profile of folliculogenesis in oocyte donors during ovarian stimulation in the follicular and luteal phases of the menstrual cycle.
Materials and methods: This study included 30 oocyte donors who underwent ovarian stimulation in both the follicular and luteal phases of the menstrual cycle. Sixty donor stimulation cycles were analyzed. Hormone levels (LH, estradiol, progesterone) were measured on the day of stimulation, day 6 of stimulation, day of ovulation trigger administration, and day of transvaginal ovarian puncture (TOP). The number of retrieved oocytes and the MII of oocytes were also evaluated.
Results: Statistically significant differences were observed between the groups in the levels of LH, estradiol, and progesterone on the day of the superovulation stimulation. There were no significant differences in estradiol levels on day 6 of stimulation, on the day of ovulation trigger administration, or on the day of TOP (p>0.05). Progesterone levels were significantly higher during the luteal phase ovarian stimulation on the day of ovarian stimulation (p<0.001) and on day 6 of stimulation (p<0.001). However, on the day of ovulation trigger administration, the progesterone levels in the study groups were similar, and on the day of TOP, progesterone levels were also comparable, regardless of the stimulation phase. There were no statistically significant differences in the number of retrieved oocytes and mature oocytes during the stimulation of donors in the different phases of the cycle (p>0.1).
Conclusion: Ovarian stimulation in the luteal phase of the menstrual cycle in oocyte donors is significantly different from ovarian stimulation in the follicular phase of the menstrual cycle in terms of the hormonal profile. However, the characteristics identified do not adversely affect the ovarian response and the production of quality oocytes.
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About the authors
Vera S. Lapina
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: v_lapina@oparina4.ru
obstetrician-gynecologist at the 1st Gynecology Department
Russian Federation, MoscowBella A. Martazanova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: dr.bella.ivf@gmail.com
Ph.D., Senior Researcher at the 1st Gynecology Department
Russian Federation, MoscowEvelina R. Durinyan
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: evelina_durinyan@mail.ru
Ph.D., Clinical Care Supervisor at the 1st Gynecology Department
Russian Federation, MoscowTatiana S. Amyan
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: t_amyan@oparina4.ru
Ph.D., Junior Researcher at the 1st Gynecology Department
Russian Federation, MoscowAnna I. Korolkova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: korolkovaai@icloud.com
Ph.D., Researcher at the 1st Gynecology Department
Russian Federation, MoscowAlla A. Gavisova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: a_gavisova@oparina4.ru
Ph.D., Head of the 1st Gynecology Department
Russian Federation, MoscowReferences
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