Reproductive function in patients with endocrine infertility

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Abstract

Objective: To analyze the restoration of reproductive function in endocrine infertility in women living in Altai Krai.

Materials and methods: The study included 1610 women with ovulation disorders out of 9325 who had sought counseling for infertility from April 27, 2001, to December 31, 2020. According to the classifications relevant during the study period, WHO (1973), and NICE (2013), all women were divided into three groups according to the nature of ovulatory dysfunction. The study analyzed gynecological and extragenital pathology among the groups and the influence of the type of ovulatory dysfunction on the choice of treatment strategy. The results of overcoming infertility in patients are presented.

Results: The anovulatory infertility rate in the entire cohort was 19.6%. The clinical differences among the three study groups were clarified. Information is presented on the restoration of the reproductive function of women with impaired ovulation in real clinical practice. The advantages and disadvantages of various management strategies, from expectant to ART, are presented. Algorithms have been developed to improve the efficiency of reproductive function in anovulatory infertility.

Conclusion: The success in the fulfillment of reproductive potential depends on the correct diagnosis of the causes of ovulation disorders and the choice of a rational way to overcome infertility, considering its clinical and pathogenetic forms. It is advisable to use assisted reproductive technologies when other treatments are ineffective or when multiple factors contribute to infertility. In a hypergonadotropic state, ART using donor oocytes is a rational way to overcome infertility.

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About the authors

Viacheslav V. Vostrikov

Altai State Medical University of the Ministry of Health of the Russian Federation; Siberian Institute of Human Reproduction and Genetics

Author for correspondence.
Email: wkoctar@mail.ru
ORCID iD: 0000-0002-5567-2758

PhD, Аssociate Professor at the Department of Obstetrics and Gynecology

Russian Federation, Barnaul; Barnaul

Tatyana А. Nazarenko

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: wkoctar@mail.ru
ORCID iD: 0000-0002-5823-1667

Dr. Med. Sci., Director of the Institute of Reproductive Medicine

Russian Federation, Moscow

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2. Fig. 1. Study design

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3. Fig. 2. Algorithm of management of patients with anovulatory infertility

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