Improving management strategy for patients with polyhydramnios

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Abstract

Objective: To evaluate the effectiveness of combination therapy in patients with virus-induced polyhydramnios.

Materials and methods: The study included 82 patients with polyhydramnios who had a new coronavirus infection COVID-19. The patients of the main group received combination treatment with indomethacin and immunomodulator Superlymph, the patients of the control group were treated with systemic antibiotics.

Results: The average size of the maximum pocket in the patients of the main group was 12.42 cm at the start of treatment, it decreased to 10.5 cm on the 3rd day and normalized in 19.23% of patients. Amniotic fluid volume was normalized on the 10th day from the start of therapy in 51.92% of patients, mild polyhydramnios persisted in 44.23% of women, moderate polyhydramnios was noted in 3.85% of patients. After two weeks from the start of treatment, amniotic fluid volume was completely normalized in 78.85%, mild polyhydramnios persisted in 15.38%, moderate polyhydramnios was observed in 5.77%. The diagnosis of polyhydramnios was eliminated in 92.31% of the patients after three weeks. The effectiveness of treatment was 60% in the control group. The size of the maximum pocket was 12.57 cm at the start of treatment, it was 10.2 cm on the 7th day; on the 14th day after the end of therapy, mild polyhydramnios persisted in 23.33% of patients and moderate polyhydramnios was noted in 16.67% of patients.

Conclusion: It is possible to prescribe combination therapy with indomethacin and immunomodulator Superlymph for patients with polyhydramnios. The results of the study showed a decrease in amniotic fluid volume according to ultrasound data and they did not affect perinatal outcomes.

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About the authors

Yulia E. Dobrokhotova

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Author for correspondence.
Email: pr.dobrohotova@mail.ru
ORCID iD: 0000-0002-7830-2290

Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, Faculty of Medicine

Russian Federation, Moscow

Ekaterina I. Borovkova

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: Katyanikitina@mail.ru
ORCID iD: 0000-0001-7140-262X

Dr. Med. Sci., Associate Professor, Professor, Department of Obstetrics and Gynecology

Russian Federation, Moscow

Tamara N. Belousova

Vidnovsky Perinatal Center

Email: beltamara1@mail.ru
ORCID iD: 0000-0003-3804-7691

PhD, Chief Physician

Russian Federation, Moscow region

Marina V. Burdenko

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: bmv-0306@rambler.ru
ORCID iD: 0000-0002-0304-4901

PhD, Associate Professor, Department of Obstetrics and Gynecology

Russian Federation, Moscow

Ilyas A. Kulikov

Vidnovsky Perinatal Center

Email: aesculap@inbox.ru
ORCID iD: 0000-0002-2460-1623

PhD, Head of the Obstetric Department of Pregnancy Pathology

Russian Federation, Moscow region

Elena A. Vdovichenko

Vidnovsky Perinatal Center

Email: aesculap@inbox.ru

Obstetrician-Gynecologist, Department of Pregnancy Pathology

Russian Federation, Moscow region

Daria S. Davydova

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: dashadavydova1215@gmail.com
ORCID iD: 0000-0002-6598-9310

Clinical Resident, Department of Obstetrics and Gynecology, Faculty of Medicine

Russian Federation, Moscow

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2. Figure. Dynamics of amniotic fluid volume changes in the patients of the main group

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