Risk of thrombotic complications in patients with ovarian cancer and some safety aspects of using antifibrinolytic hemostatic agents

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Abstract

The risk of thrombotic complications is known to increase several times in cancer patients. The malignant process causes changes in the blood coagulation and fibrinolytic systems which negatively affect the prognosis of the patient’s complications. The tumors of the female reproductive system, especially ovarian cancer, are among the most thrombogenic solid tumors. The level of specific markers increases particularly in patients with ovarian cancer. These markers can help to identify patient’s predisposition to the rapid development of venous thromboembolism. There are certain risk factors that increase the likelihood of thrombosis in ovarian cancer: age over 60 years, excess body weight, tumor diameter of more than 100 mm, and the presence of ascites and chronic diseases. Medications used for ovarian cancer are also worth noting. The use of antitumor drugs is known to contribute to thrombotic complications.

Conclusion: There is an active discussion about the increased risk of venous thromboembolism in patients who received tranexamic acid and other antifibrinolytic agents to reduce intraoperative blood loss. Although some studies have confirmed the effectiveness of tranexamic acid, there are currently not enough randomized trials to guarantee the absence of a link between the use of antifibrinolytic agents and venous thromboembolism in patients with ovarian cancer. The reasonable use of this group of drugs with obligatory thromboprophylaxis is recommended.

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About the authors

Viktoriya A. Deryabina

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: vika.deryabina@mail.ru

4th year student of the Pediatric Faculty

Russian Federation, Saint Petersburg

Valeriy I. Matukhin

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: val-matukhin@mail.ru
ORCID iD: 0000-0002-8906-8356

Assistant at the Department of Obstetrics and Gynecology

Russian Federation, Saint Petersburg

Nikolai N. Rukhliada

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: nickolasr@mail.ru
ORCID iD: 0000-0002-3548-0468

Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology

Russian Federation, Saint Petersburg

Victoria N. Abramova

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: abramova_vn@mail.ru

obstetrician-gynecologist of the Gynecological Department

Russian Federation, Saint Petersburg

Elena E. Kuts

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Author for correspondence.
Email: elenakuts999@gmail.com

Assistant of the Department of Obstetrics and Gynecology

Russian Federation, Saint Petersburg

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