Early diagnosis of endometrial hyperplasia based on clinical and anamnestic factors

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Abstract

Objective: To determine clinical and anamnestic factors in the development of endometrial hyperplasia based on the analysis of the results of hysteroscopy and aspirate morphology.

Materials and method. A prospective cohort study was conducted for 3 years (2019–2021). The study included 900 women aged 20–70 years who underwent hysteroscopy and morphological assessment of the aspirate. Group I consisted of 440 women with hysteroscopically and morphologically confirmed endometrial hyperplasia, group II included 460 women without confirmed endometrial hyperplasia. In all cases, the indication for hysteroscopy were menstrual irregularities of unknown etiology, the pathological process that was detected or suspected during ultrasound examination.

Results: Statistically significant differences in clinical and anamnestic factors were found between the women with hysteroscopically and morphologically confirmed endometrial hyperplasia and the women without confirmed endometrial hyperplasia. Based on the obtained data, a computer program was developed using logistic regression for detection of endometrial hyperplasia. The sensitivity of this detection method was 88.7%, and the specificity was 92.6%. The computer program "Clinical and anamnestic factors for early diagnosis of endometrial hyperplasia" was submitted for registration to the Federal Service for Intellectual Property (Moscow).

Conclusion: The program "Clinical and anamnestic factors for early diagnosis of endometrial hyperplasia" can be recommended for routine use for detection of endometrial hyperplasia and carrying out therapeutic measures.

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About the authors

Yuliya S. Frolova

Kemerovo City Clinical Hospital No. 4

Author for correspondence.
Email: beletskaya91@inbox.ru

obstetrician-gynecologist

Russian Federation, 650025, Kemerovo, Basovaya str., 12a

Svetlana I. Elgina

Kemerovo State Medical University of the Ministry of Health of Russia

Email: Elginas.i@mail.ru
ORCID iD: 0000-0002-6966-2681

Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology named after G.A. Ushakova

Russian Federation, 650056, Kemerovo, Voroshilova str., 22a.

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