Possibilities of antibacterial therapy in patients with mixed infections of the vagina and cervix: the results of the Flora Centrum study

Objective: To evaluate the efficacy and safety of the use of the Symprazole combined drug (ornidazole 500 mg + ciprofloxacin 500 mg) in women with mixed bacterial infections of the vagina and cervix which are caused by sensitive Gram+ and Gram- microorganisms in combination with anaerobic microorganisms in real clinical practice.

Materials and methods: The study included 40 women aged 18 to 50 years with mixed bacterial infections of the vagina and cervix confirmed by laboratory tests. The study consisted of three periods: selection of patients (initial assessment and analysis), inclusion in the study and initiation of therapy, evaluation of the effectiveness of therapy and control analyses. The schedule of patients’ visits was determined based on actual clinical practice. The participation of each patient in the study did not exceed 49 days. The total duration of the course of treatment with the Symprazole drug was determined by the researcher and ranged from 5 to 7 days: one tablet was taken twice a day.

Results: The clinical efficacy of the therapy of the above drug was 97.5%, and the microbiological efficacy was 95%. During the course of treatment, there was an improvement in clinical symptoms: the absence of discomfort, itching, burning, mucosal hyperemia, and a decrease in symptoms of dyspareunia. A fast clinical effect (complete absence of complaints after 36–72 hours) was observed in 92.7% of patients. Microbiological picture improved when laboratory parameters of vaginal microbiocenosis were normalized. After the end of the course of therapy (after 35–37 days), there was a significant decrease in the intensity of colonization by opportunistic microorganisms in the vaginal biotope of patients and there were representatives of normal biocenosis. The Symprazole drug has shown its high safety, no adverse events have been detected during its use.

Conclusion: The original combination Symprazole drug has shown its high effectiveness and rapid onset of clinical effect in the treatment of mixed bacterial infections of the vagina and cervix caused by Gram+ and Gram- microorganisms in combination with anaerobic flora.