The variability in the clinical effects of indolcarbinol in women with mastodynia

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Abstract

Objective: To present the experience of using indolcarbinol in patients with fibrocystic mastopathy.

Materials and methods: These are the results of monitoring the use of indolcarbinol for 6 months in 81 women aged 40–45 years with cyclic mastodynia accompanied by diffuse fibrocystic mastopathy (DFCM).

Results: The use of indolcarbinol for 6 months in women with cyclic mastodynia does not have a negative effect on the nature of the menstrual cycle. Its use is also accompanied by such positive trends as improvement of menstrual function, a significant decrease in the severity of dysmenorrhea as well as control of premenstrual syndrome, improvement of some ultrasound parameters characterizing adenomyosis. There is also a complete control of mastodynia, reduction or disappearance of edema and heterogeneity of the structure of the mammary glands during palpation and positive changes according to ultrasound of the mammary glands (restoration of the average echogenicity of the tissue, decrease in the diameter of the milk ducts and cysts, normalization of the severity of the connective tissue pattern, etc.).

Conclusion: The results of the observation confirmed the effectiveness and safety of indolcarbinol in women with cyclic mastodynia, which is accompanied by different variants of DFCM, both isolated and combined with uterine fibroids and adenomyosis, which can often be found in this cohort of patients.

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About the authors

Anna V. Vorontsova

Ural State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: a_valerevna@mail.ru
ORCID iD: 0000-0002-0509-3328
SPIN-code: 1556-6528
Scopus Author ID: 57200595728

obstetrician-gynecologist, PhD, Associate Professor, Associate Professor of the Department of Obstetrics and Gynecology with a course in medical genetics

Russian Federation, Yekaterinburg

Maxim A. Zvychayny

Ural State Medical University, Ministry of Health of Russia

Email: maksim.zvychainyi@mail.ru
ORCID iD: 0000-0003-4728-9553
SPIN-code: 7879-6711
Scopus Author ID: 57222111890

obstetrician-gynecologist, Dr. Med. Sci., Professor, Professor of the Department of Obstetrics and Gynecology with a course in medical genetics

Russian Federation, Yekaterinburg

Polina A. Guzhavina

Ural State Medical University, Ministry of Health of Russia

Email: polina_ryabkova@list.ru

resident obstetrician-gynecologist of the Department of Obstetrics and Gynecology with a course in medical genetics

Russian Federation, Yekaterinburg

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