Activation of ovarian function in patients with diminished ovarian reserve through administration of extracellular vesicles

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Abstract

Relevance: Poor response to ovarian stimulation during an IVF program is a pressing issue that limits the effectiveness of assisted reproductive technology (ART). Currently, there are no verified and effective methods in routine clinical practice to improve the success rates of treatment in patients with a poor ovarian response. The use of cell-free therapy as a preparation for IVF/ICSI programs offers a promising alternative to donor oocytes, allowing this group of patients to have genetically related children.

Case report: This article presents three clinical observations that demonstrate the effectiveness of a technique involving the activation of ovarian function through intraovarian administration of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in patients with a history of multiple IVF failures and poor response to ovarian stimulation.

Conclusion: The presented information on the efficacy of MSC-EVs, based on clinical cases of complex and challenging patients with significantly diminished ovarian function, provides hope for the development of a new direction in reproductive medicine based on the use of cellular technologies. Further research is needed to study the intraovarian regulation of folliculogenesis and the mechanisms by which extracellular vesicles influence these processes.

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About the authors

Yana O. Martirosyan

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Author for correspondence.
Email: marti-yana@yandex.ru
ORCID iD: 0000-0002-9304-4410

Junior Researcher at the F. Paulsen Research and Educational Center for ART

Russian Federation, Moscow

Tatiana A. Nazarenko

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: t.nazarenko@mail.ru
ORCID iD: 0000-0002-5823-1667

Dr. Med. Sci., Head of the Institute of Reproductive Technologies

Russian Federation, Moscow

Albina I. Kadaeva

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: albina.karimovai@mail.ru

PhD student

Russian Federation, Moscow

Kirill V. Goryunov

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: k_gorunov@oparina4.ru
ORCID iD: 0000-0002-8776-7196

PhD (Bio), Researcher at the Laboratory of Cell Technologies

Russian Federation, Moscow

Yulia A. Shevtsova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: yu_shevtsova@oparina4.ru

Junior Researcher at the Laboratory of Cell Technologies

Russian Federation, Moscow

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