A profile of autoantibodies to steroid hormones and steroidogenic enzymes in women with endometriosis

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Endometriosis is a chronic inflammatory disease that affects women of reproductive age and is characterized by the presence of a wide range of autoantibodies, including those directed against steroid hormones. Of particular scientific interest is the detection of autoantibodies to steroidogenic enzymes, which have been identified as a risk factor for premature ovarian insufficiency (POI).

Objective: To study the profile of autoantibodies to steroid and gonadotropic hormones, and steroidogenic enzymes, in women with endometriosis.

Materials and methods: Using enzyme immunoassay, serum antibodies to estradiol, progesterone, follicle-stimulating hormone, and steroidogenic enzymes (21-hydroxylase, aromatase, cholesterol side-chain cleavage enzyme) were determined in patients with ovarian and deep infiltrating endometriosis (n=45) and in women without endometriosis (n=20).

Results: In patients with endometriosis, in addition to the predominant antibodies to estradiol and progesterone (60% and 55.6%, respectively), antibodies (M and G) to steroidogenic enzymes were detected. The detection rate and odds of detecting these antibodies were higher (33.3%, OR=9.5) than those in the control group (5%). Combinations of several antibodies against enzymes were observed in patients with severe endometriosis.

Conclusion: In addition to the high prevalence of autoantibodies to steroid hormones, patients with endometriosis are highly likely to have antibodies to steroidogenic enzymes. The latter may contribute to the development of autoimmune POI and infertility. The study will continue with a larger sample size and broader range of laboratory and instrumental parameters.

全文:

受限制的访问

作者简介

Irina Menzhinskaya

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: i_menzinskaya@oparina4.ru

Dr. Med. Sci., Leading Researcher, Laboratory of Clinical Immunology

俄罗斯联邦, 117997, Moscow, Oparin str., 4

Stanislav Pavlovich

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation; Perinatology and Reproductology, Institute of Vocational Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: s_pavlovich@oparina4.ru

PhD, Scientific Secretary, Professor, Department of Obstetrics, Gynecology, Perinatology and Reproductology

俄罗斯联邦, 117997, Moscow, Oparin str., 4; Moscow

Arika Melkumyan

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: Dr.melkumyan@gmail.com

Obstetrician-Gynecologist

俄罗斯联邦, 117997, Moscow, Oparin str., 4

Vladimir Chuprynin

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: v_chuprynin@oparina4.ru

PhD, Head of the Department of Surgery

俄罗斯联邦, 117997, Moscow, Oparin str., 4

参考

  1. Taylor H.S., Kotlyar A.M., Flores V.A. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet. 2021; 397(10276): 839-52. https://dx.doi.org/10.1016/S0140-6736(21)00389-5.
  2. Becker C.M., Bokor A., Heikinheimo O., Horne A., Jansen F., Kiesel L. et al.; ESHRE Endometriosis Guideline Group. ESHRE guideline: endometriosis. Hum. Reprod. Open. 2022; 2022(2): hoac009. https://dx.doi.org/10.1093/hropen/hoac009.
  3. Gajbhiye R.K. Endometriosis and inflammatory immune responses: Indian experience. Am. J. Reprod. Immunol. 2023; 89(2): e13590. https:// dx.doi.org/10.1111/aji.13590.
  4. Smolarz B., Szyłło K., Romanowicz H. Endometriosis: epidemiology, classification, pathogenesis, treatment and genetics (review of literature). Int. J. Mol. Sci. 2021; 22(19): 10554. https://dx.doi.org/10.3390/ijms221910554.
  5. Cuffaro F., Russo E., Amedei A. Endometriosis, pain, and related psychological disorders: unveiling the interplay among the microbiome, inflammation, and oxidative stress as a common thread. Int. J. Mol. Sci. 2024; 25(12): 6473. https://dx.doi.org/10.3390/ijms25126473.
  6. Practice Committee of the American Society for Reproductive Medicine. Endometriosis and infertility: a committee opinion. Fertil. Steril. 2012; 98(3): 591-8. https://dx.doi.org/10.1016/j.fertnstert.2012.05.031.
  7. Van Gestel H., Bafort C., Meuleman C., Tomassetti C., Vanhie A. The prevalence of endometriosis in unexplained infertility: a systematic review. Reprod. Biomed. Online. 2024; 49(3): 103848. https://dx.doi.org/10.1016/j.rbmo.2024.103848.
  8. Suszczyk D., Skiba W., Pawłowska-Łachut A., Dymanowska-Dyjak I., Włodarczyk K., Paduch R. et al. Immune checkpoints in endometriosis – a new insight in the pathogenesis. Int. J. Mol. Sci. 2024; 25(11): 6266. https:// dx.doi.org/10.3390/ijms25116266.
  9. Greenbaum H., Galper B.L., Decter D.H., Eisenberg V.H. Endometriosis and autoimmunity: can autoantibodies be used as a non-invasive early diagnostic tool? Autoimmun. Rev. 2021; 20(5): 102795. https://dx.doi.org/10.1016/ j.autrev.2021.102795.
  10. Shigesi N., Kvaskoff M., Kirtley S., Feng Q., Fang H., Knight J.C. et al. The association between endometriosis and autoimmune diseases: a systematic review and meta-analysis. Hum. Reprod. Update. 2019; 25(4): 486-503. https://dx.doi.org/10.1093/humupd/dmz014.
  11. Nisenblat V., Bossuyt P.M., Shaikh R., Farquhar C., Jordan V., Scheffers C.S. et al. Blood biomarkers for the non-invasive diagnosis of endometriosis. Cochrane Database Syst. Rev. 2016; 2016(5): CD012179. https:// dx.doi.org/10.1002/14651858.CD012179.
  12. Menzhinskaya I.V., Pavlovich S.V., Melkumyan A.G., Chuprynin V.D., Yarotskaya E.L., Sukhikh G.T. Potential significance of serum autoantibodies to endometrial antigens, α-enolase and hormones in non-invasive diagnosis and pathogenesis of endometriosis. Int. J. Mol. Sci. 2023; 24(21): 15578. https://dx.doi.org/10.3390/ijms242115578.
  13. Adamyan L.V., Menzhinskaya I.V., Antonova A.A., Tonoyan N.M., Sukhikh G.T. Diagnostic value of autoantibodies against steroidogenic enzymes and hormones in infertile women with premature ovarian insufficiency. Int. J. Mol. Sci. 2024; 25(12): 6545. https://dx.doi.org/10.3390/ijms25126545.
  14. Webber L., Davies M., Anderson R., Bartlett J., Braat D., Cartwright B. et al.; European Society for Human Reproduction and Embryology (ESHRE) Guideline Group on POI. ESHRE Guideline: management of women with premature ovarian insufficiency. Hum. Reprod. 2016; 31(5): 926-37. https://dx.doi.org/10.1093/humrep/dew027.
  15. Менжинская И.В., Мелкумян А.Г., Павлович С.В., Чупрынин В.Д., Кречетова Л.В. Сравнение профиля сывороточных аутоантител у женщин при разных формах эндометриоза. Акушерство и гинекология. 2023; 8: 78-85. [Menzhinskaya I.V., Melkumyan A.G., Pavlovich S.V., Chuprynin V.D., Krechetova L.V. Comparison of the profile of serum autoantibodies in women with different forms of endometriosis. Obstetrics and Gynecology. 2023; (8): 78-85 (in Russian)]. https://dx.doi.org/10.18565/aig.2023.105.
  16. Maksym R.B., Hoffmann-Młodzianowska M., Skibińska M., Rabijewski M., Mackiewicz A., Kieda C. Immunology and immunotherapy of endometriosis. J. Clin. Med. 2021; 10(24): 5879. https://dx.doi.org/10.3390/jcm10245879.
  17. Zhang T., De Carolis C., Man G.C.W., Wang C.C. The link between immunity, autoimmunity and endometriosis: a literature update. Autoimmun. Rev. 2018; 17(10): 945-55. https://dx.doi.org/10.1016/j.autrev.2018.03.017.
  18. Hever A., Roth R.B., Hevezi P., Marin M.E., Acosta J.A., Acosta H. et al. Human endometriosis is associated with plasma cells and overexpression of B lymphocyte stimulator. Proc. Natl. Acad. Sci. U S A. 2007; 104(30): 12451-6. https://dx.doi.org/10.1073/pnas.0703451104.
  19. Louwen F., Kreis N.N., Ritter A., Friemel A., Solbach C., Yuan J. BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis. Hum. Reprod. Update. 2022; 28(6): 890-909. https://dx.doi.org/10.1093/humupd/dmac027.
  20. Riccio L.G.C., Baracat E.C., Chapron C., Batteux F., Abrão M.S. The role of the B lymphocytes in endometriosis: a systematic review. J. Reprod. Immunol. 2017; 123: 29-34. https://dx.doi.org/10.1016/j.jri.2017.09.001.
  21. Miller W.L., Auchus R.J. The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr. Rev. 2011; 32(1): 81-151. https://dx.doi.org/10.1210/er.2010-0013.
  22. Bulun S.E., Yilmaz B.D., Sison C., Miyazaki K., Bernardi L., Liu S. et al. Endometriosis. Endocr. Rev. 2019; 40(4): 1048-79. https://dx.doi.org/10.1210/er.2018-00242.
  23. Han S.J., Hawkins S.M., Begum K., Jung S.Y., Kovanci E., Qin J. et al. A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat. Med. 2012; 18(7): 1102-11. https://dx.doi.org/10.1038/nm.2826.
  24. Савина В.А., Потин В.В., Тарасова М.А. Роль ароматазы в патогенезе первично-овариальной недостаточности. Журнал акушерства и женских болезней. 2010; 59(6): 85-93. [Savina V.A., Potin V.V., Tarasova M.A. The role of aromatase in the pathogenesis of primary ovarian deficiency (literature review). Journal of Obstetrics and Women's Diseases. 2010; 59(6): 85-93. (in Russian)].
  25. Hobeika E., Armouti M., Kala H., Fierro M.A., Winston N.J., Scoccia B. et al. Oocyte-secreted factors synergize with FSH to promote aromatase expression in primary human cumulus cells. J. Clin. Endocrinol. Metab. 2019; 104(5): 1667-76. https://dx.doi.org/10.1210/jc.2018-01705.

补充文件

附件文件
动作
1. JATS XML
下载
2. Fig. 1. Frequency of detection of autoantibodies of classes M and 6 in total to steroidogenic enzymes (CYP11A1, CYP19A1, CYP21A2), steroid (estradiol, progesterone) and gonadotropic (FSH) hormones in the blood serum of patients with endometriosis (group 1) and without endometriosis (group 2). *p<0.05 when comparing two groups

下载 (189KB)
索引源数据
3. Fig. 2. Correlation between the levels of serum autoantibodies of classes M and C to steroidogenic enzymes (CYP11A1, CYP19A1, CYP21A2), steroid (estradiol, progesterone) and gonadotropic (FSH) hormones in patients with endometriosis. *p<0.05

下载 (329KB)
索引源数据

版权所有 © Bionika Media, 2024