Structural assessment of the fetal brain in late-onset fetal growth restriction using magnetic resonance imaging

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Objective: To assess the volumes of fetal anatomical structures using magnetic resonance imaging (MRI) in pregnant women with late-onset fetal growth restriction (FGR) and small-for-gestational-age (SGA) fetuses.

Materials and methods: This prospective cohort study included 15 pregnant women with late-onset FGR and 15 pregnant women with SGA who underwent MRI. The control group consisted of nine pregnant women with appropriate-for-gestational-age fetuses. Using manual selection of the regions of interest, the volumes of the supratentorial brain and cerebellum were measured, and their ratios were calculated. Quantitative measurements of all the brain structures were converted to percentile values.

Results: The percentile values of supratentorial brain and cerebellum volumes were significantly smaller in the late-onset FGR group (p=0.004 and p<0.001, respectively). There were no statistically significant differences in the volume of the brain structures in the SGA group.

Conclusion: Fetuses with late-onset fetal growth restriction have reduced supratentorial brain and cerebellar volumes, as assessed by MRI, compared with controls. Placental insufficiency in late-onset FGR has a greater effect on brain volume than on birth weight. Further studies are needed to clarify the areas of interest in the brain and to determine their association with the severity and likelihood of reversibility of neurological deficits in newborns and infants with late-onset fetal growth restriction.

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作者简介

Elizaveta Stoliarova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: ev_stolyarova@oparina4.ru
ORCID iD: 0009-0001-2049-3119

PhD student, 1st Obstetric Department of Pregnancy Pathology

 

俄罗斯联邦, 117997, Moscow, Ac. Oparin str., 4

Alexey Kholin

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: a_kholin@oparina4.ru
ORCID iD: 0000-0002-4068-9805

PhD, Head of the Department of Telemedicine

俄罗斯联邦, 117997, Moscow, Ac. Oparin str., 4

Egor Syrkashev

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: e_syrkashev@oparina4.ru
ORCID iD: 0000-0003-4043-907X

PhD, Senior Researcher at the Radiology Department

俄罗斯联邦, 117997, Moscow, Ac. Oparin str., 4

Zulfiya Khodzhaeva

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: z_khodzhaeva@oparina4.ru
ORCID iD: 0000-0001-8159-3714

Dr. Med. Sci, Professor, Deputy Director, Institute of Obstetrics

俄罗斯联邦, 117997, Moscow, Ac. Oparin str., 4

Aleksandr Gus

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation; Patrice Lumumba Peoples' Friendship University of Russia

Email: a_gus@oparina4.ru
ORCID iD: 0000-0003-1377-3128

Dr. Med. Sci., Chief Researcher at the Department of Ultrasound and Functional Diagnostics, Head of the Department of Ultrasound Diagnostics, Medical Institute of Patrice Lumumba Peoples’ Friendship University of Russia

俄罗斯联邦, 117997, Moscow, Ac. Oparin str., 4; 117198, Moscow, Miklukho-Maklaya st., 6

参考

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1. JATS XML
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2. Fig. 1. Anatomical boundaries of the supratentorial brain and cerebellum on fetal MRI

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3. Fig. 2. Distribution of cases in groups with IGR, MGV, SGV (control) depending on the gestational age at the time of MRI

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4. Fig. 3. Percentile values ​​of the volume of the supratentorial brain of the fetus in the groups with IGR, MGV and SGV (control). *p<0.05

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5. Fig. 4. Percentile values ​​of fetal cerebellum volume in groups with IUGR, MGV and SGV (control). *p<0.05

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