Pathogenesis, diagnosis, and treatment of genital endometriosis: current state of the issue

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Abstract

Endometriosis is the most common condition in young women. This review presents the analysis of the recent studies on the etiology, pathogenesis of the disease, and risk factors for its development. The search for non-invasive markers for the early diagnosis of endometriosis led to the involvement of artificial intelligence and the development of specialised software. In order to meet the needs of the practitioner, the classification of endometriosis has been modernized. The search for drugs aimed at pathogenetic treatment of the disease as well as its prevention with high safety and efficacy continues. Every year there are improvements in surgical techniques using artificial intelligence and robotics.

Conclusion: There is a high need for basic research on the endometriosis pathophysiology in the fields of genomics, proteomics, transcriptomics, metabolomics, combined with the study of the characteristics of immunological surveillance and endocrine dysregulation. This type of research would help clarify the specific mechanisms of endometriosis pathogenesis and identify new diagnostic and therapeutic targets.

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About the authors

Angelina K. Krasilnikova

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia

Author for correspondence.
Email: brasilia71@mail.ru
ORCID iD: 0000-0001-7839-3893

Dr. Med. Sci., Senior Researcher at the Department of Obstetrics and Gynecology

Russian Federation, 153045, Ivanovo, Pobedy str., 20

Elena L. Boyko

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia

Email: Dr-Boyko@mail.ru
ORCID iD: 0000-0002-8907-4860

Dr. Med. Sci., Senior Researcher at the Department of Obstetrics and Gynecology

Russian Federation, 153045, Ivanovo, Pobedy str., 20

Anna I. Malyshkina

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia

Email: anna_im@mail.ru
ORCID iD: 0000-0002-1145-0563

Dr. Med. Sci., Professor, Director

Russian Federation, 153045, Ivanovo, Pobedy str., 20

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