Prognostic value of vascular cell adhesion molecules in the evaluation of the severity of gestosis


Cite item

Full Text

Abstract

Objective: to determine the clinical and diagnostic value of sVCAM1 in the development of endotheliosis in gestosis. Setting: Department of Obstetrics and Gynecology, Faculty for Postgraduate Education of Physicians, I. M. Sechenov Moscow Medical Academy; V. P. Serbsky State Research Center of Social Forensic Psychiatry, Moscow Design: a prospective study. Subjects: 68 pregnant women, including 24, 25, and 19 patients with mild, moderate, and severe gestosis, respectively, as well as 25 apparently healthy pregnant women (a comparison group). Methods: clinical and statistical studies, enzyme immunoassay. Results: blood sVCAM1 is detectable in subthreshold concentrations in patients with physiological pregnancy. When gestosis develops, the expression of cell adhesion molecules begins to increase at gestational week 22. There is a direct correlation between the level of sVCAM1 in varying gestosis with its clinical manifestations (the degree of proteinuria, edema, and blood pressure). There is a direct relationship between the degree of endotheliosis, the severity of gestosis, and the concentration of sVCAM1. Conclusion: sVCAM1 may be used to diagnose and predict gestosis.

Full Text

Restricted Access

References

  1. Акушерство и гинекология: Клинические рекомендации / Под ред. В. И. Кулакова. - М., 2005.
  2. Караганов Я. Л. // Арх. анаг. - 1972. - Т, 71, № 1. - С. 15.
  3. Кулаков В. И., Фролова О. Г., Токова З. З. // Акуш. и гин. - 2004. - № 2. - С. 3-5.
  4. Липатов И. С. Клиническая оценка иммунных проявлений повреждения сосудистой стенки при физиологической и осложненной гестозом беременности: Дис.. канд. мед. наук. - Самара, 1993.
  5. Стриженов А. Н., Мусаев З. М., Меликова Н. Л., Мельников В. А. // Акуш. и гин. - 2000. - № 3. - С. 14-17.
  6. Фролова О. Г., Токова З. З., Пугачева Т. П., Гудимова В. В. // Материалы 36-го Конгресса Международного о-ва по изучению патофизиологии беременности. - М., 2004. - С. 269-270.
  7. Шифман Е. М. Преэклампсия, эклампсия, HELLP-синдром. - Петрозаводск, 2003.
  8. Ara J., Mirapeix E., Arrizabalaga P., Rodrigez R. // Nephrol. Dial. Transplant. - 2001. - Vol. 16, - P. 276-285.
  9. Blaauw J., Craaff R., van Pampas M. G. et al. // Obstetr. and Gynecol, - 2005. - Vol. 105, N 3. - P. 626-632.
  10. Borzychowski A. M., Sargent I. L., Redman C. W. H. // Semin, Fetal Neonatal Med. - 2006. - Vol. 11. - P. 309-316.
  11. Conde-Agudela A., Villar J., Lindheimer M. // Obstetr. and Gynecol. - 2004. - Vol. 104. N 6. - P. 1367-1391,
  12. Davison J. M., Homuth V., Jeyabalan A., Conrad K. P. // J. Am. Soc. Nephrol. - 2004. - Vol. 15. - P. 2440-2448.
  13. Goswami D., Tannetta D. S., Magee L. A. et al. // Placenta. - 2006. - Vol. 27, N 1, - P. 56-61.
  14. Haller H., Ziegler E. M., Homuth V. et al. // Hypertension. - 1997. - Vol. 29, N 2. - P. 291-296.
  15. Khan F., Belch J. J., MacLeod M., Mires G. // Hypertension. - 2005. - Vol. 46, N 5. - P. 1123-1128.
  16. Kim S. Y., Ryu H. M. // J. Korean Med. Sei. - 2004. - Vol. 19. - P. 688-692.
  17. Luppi P., Deloia J. A. // Clin. Immunol. - 2000. - Vol. 118, N 2-3. - P. 268-275.
  18. Raouf A., Khalil C., Granger P. // Am. J. Physiol. Regul. Integrat. Comp. Physiol. - 2002. - Vol. 283. - P. R29-R45.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2008 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies