Prognostic value of vascular cell adhesion molecules in the evaluation of the severity of gestosis
- Autores: Shemanayeva T.V.1, Sidorova I.S.1, Gurina O.I.1, Borovkova Y.I.1
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Afiliações:
- Edição: Nº 2 (2008)
- Páginas: 16-18
- Seção: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246042
- ID: 246042
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Resumo
Objective: to determine the clinical and diagnostic value of sVCAM1 in the development of endotheliosis in gestosis. Setting: Department of Obstetrics and Gynecology, Faculty for Postgraduate Education of Physicians, I. M. Sechenov Moscow Medical Academy; V. P. Serbsky State Research Center of Social Forensic Psychiatry, Moscow Design: a prospective study. Subjects: 68 pregnant women, including 24, 25, and 19 patients with mild, moderate, and severe gestosis, respectively, as well as 25 apparently healthy pregnant women (a comparison group). Methods: clinical and statistical studies, enzyme immunoassay. Results: blood sVCAM1 is detectable in subthreshold concentrations in patients with physiological pregnancy. When gestosis develops, the expression of cell adhesion molecules begins to increase at gestational week 22. There is a direct correlation between the level of sVCAM1 in varying gestosis with its clinical manifestations (the degree of proteinuria, edema, and blood pressure). There is a direct relationship between the degree of endotheliosis, the severity of gestosis, and the concentration of sVCAM1. Conclusion: sVCAM1 may be used to diagnose and predict gestosis.
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