The pattern of changes in angiogenetic markers in gestosis
- Authors: Sidorova IS1, Makarov I.O.1, Solonitsyn AN1, Borovkova EI1, Bilyavskaya OS1, Sidorova IS2, Makarov IO2, Solonitsyn AN2, Borovkova Y.I2, Bilyavskaya OS2
-
Affiliations:
- I. M. Sechenov Moscow Medical Academy
- Issue: No 3 (2009)
- Pages: 38-41
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246110
- ID: 246110
Cite item
Full Text
Abstract
It was ascertained that the third trimester of uncomplicated pregnancy was characterized by reduced PlGF concentrations and elevated sFlt-1 levels; the content of VEGF-A significantly unchanged. In proportion to progressive gestosis, there was a reduction in the concentration of VEGF-A and PlGF and an increase in the levels of sFlt-1. The changes in the concentrations of sFlt-1 and PlGF were associated with elevated BPmean, the degree of proteinuria and edemas in gestosis. The detected changes in the study factors of angiogenesis are related to the major clinical manifestations of gestosis and reflect the severity of its course.
Keywords
About the authors
I S Sidorova
Igor' Olegovich Makarov
A N Solonitsyn
E I Borovkova
O S Bilyavskaya
I S Sidorova
I. M. Sechenov Moscow Medical Academy; I. M. Sechenov Moscow Medical Academy
I O Makarov
I. M. Sechenov Moscow Medical Academy; I. M. Sechenov Moscow Medical Academy
A N Solonitsyn
I. M. Sechenov Moscow Medical Academy; I. M. Sechenov Moscow Medical Academy
Ye I Borovkova
I. M. Sechenov Moscow Medical Academy; I. M. Sechenov Moscow Medical Academy
O S Bilyavskaya
I. M. Sechenov Moscow Medical Academy; I. M. Sechenov Moscow Medical Academy
References
- Бурлев В. А., Зайдиева З. С., Тютюнник В. Л. // Пробл. репрод. - 2001. - № 7. - С. 31-34.
- Бурлев В. А., Зайдиева З. С., Тютюнник В. Л. и др. // Материалы 36-го Ежегодного конгресса международного о-ва по изучению патофизиологии беременности организации гестоза. - М., 2004. - С. 32-33.
- Игнатко И. В., Давыдов А. И., Рыбин М. В. // Вопр. гиг., акуш. и перинатол. - 2006. - Т. 5, № 6. - С. 68-74.
- Методические указания № 99/80: "Современные подходы к диагностике, профилактике и лечению гестоза". - М., 1999.
- Сидорова И. С. Гестоз. - М., 2003.
- Стрижаков А. Н., Мусаев З. М., Меликова Н. Л., Мельников В. А. // Акуш. и гин. - 2000. - № 3. - С. 14-21.
- Athanassiades A., Hamilton G. S., Lala P. K. // Biol. Reprod. - 1998. - Vol. 59, N 4. - P. 643-654.
- Breier G. // Placenta. - 2000. - Vol. 21, N 2. - P. 11-15.
- Crocker I. P., Strachan B. K., Lash G. E. et al. // J. Soc. Gynecol. Invest. - 2001. - Vol. 11, N 8. - P. 341-346.
- Davison J. M., Volker Homuth, Arun Jeyabalan et al. // J. Am. Soc. Nephrol. - 2004. - N 5. - P. 2440-2448.
- Ferrara N. // Endocr. Rev. - 2004. - Vol. 25, N 3. - P. 581-611.
- Granger J. P., Alexander B. T., Llinas M. T. et al. // Hypertension. - 2001. - Vol. 38, N 6. - P. 718-721.
- Khaliq A., Dunck C., Jiang J. et al. // Lab. Invest. - 1999. - Vol. 79, N 5. - P. 151-170.
- Lash G. E., Cartwright J. E., Whitley G. S. // Placenta. - 1999. - Vol. 20, N 4. - P. 661-667.
- Maynard S. E., Min J. Y., Merchan J. et al. // J. Clin. Invest. - 2003. - Vol. 11, N 7. - P. 649-658.
- Ong S., Lash G., Baker P. N. // Bailliere's Best Pract. Res. Clin. Obstetr. Gynecol. - 2000. - Vol. 14, N 6. - P. 969-980.
- Torry D. S., Mykherjea D., Arroyo J. // J. Soc. Gynecol. Invest. - 2000. - Vol. 10, N 4. - P. 178-185.
- Zygmont M., Herr F., Munstedt K. et al. // Obstetr. and Gynecol. - 2003. - Vol. 110, N 3. - P. 11-18.
Supplementary files
![](/img/style/loading.gif)