The combination of systemic and local metronidazole in the treatment of bacterial vaginosis in pregnant women


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Abstract

Twenty-six pregnant women diagnosed as having bacterial vaginosis (BV) in the second and third trimesters were treated with metronidazole. The drug was administered in a daily dose of 0.5 g orally twice daily and 500 mg vaginally overnight. The treatment was proven to be highly effective and safe. Clinical and microbiological recovery occurred in all the pregnant women. Metronidazole turned out to be highly active against obligate anaerobic bacteria and Gardnerella, at the same time it failed to suppress the growth of lactobacilla, which promoted a rapid recovery of the normal concentrations of the lactoflora. There was no complication related to the treatment for BV as nonspecific vaginitis caused by facultative anaerobes. However, 3 pregnant women were observed to have signs of Candida vaginitis after treatment. The side effects (nausea, vomiting, oral metallic taste, etc.) characteristic for metronidazole were absent. The findings allow one to recommend this BV treatment regimen in the second and third trimesters of pregnancy.

References

  1. Азарова О.Ю., Демидова Е.М., Анкирская А.С. и др. Терапия бактериального вагиноза в I триместре беременности // Акуш. и гин. - 2002. № 5. - С. 43-46.
  2. Анкирская А.С. Бактериальный вагиноз // Акуш. и гин. - 2005. - № 3. - С. 10-13.
  3. Липова Е.В. Урогенитальные инфекции женщин: методологические, клинико-лабораторные подходы к диагностике и терапии. Автореф. дис. …д-ра мед. наук. - М., 2004.
  4. Липова Е.В. Альтернативные способы лечения бактериального вагиноза. // Рос. журн. кож. и вен. бол. - 2005. - № 2. - С. 54-56.
  5. Никонов А.П., Асцатурова О.Р. Вульвовагиниты // Гинекология. - 2002. - Vol. 4, N 3. - С. 122-125.
  6. Никонов А.П., Асцатурова О.Р., Шулутко П.А. и др. Инфекции мочевыводящих путей и беременность: диагностика и антибактериальная терапия // Consilium medicum. - 2006. - Т.8, № 6. -С. 71-76.
  7. Hill G.B. The microbiology of bacterial vaginosis. // Amer. J. Obstet. Gynec. - 2001. - Vol. 169. - P. 450-454.
  8. Josoet M.R., Schmid G.P. Bacterial vaginosis: review of treatment options and potential clinical indications for therapy. // Clinю Inf.Diseases. - 2005. - N 20, Suppl. 1. - P. 72-79.
  9. Koumans E.H. et al. Indications for therapy and treatment recommendations for bacterial vaginosis in nonpregnant and pregnant women. A synthesis of data // Clin. Inf. Diseases. - 2002. - Vol. 35, Suppl 2. - P. 152-172.
  10. Larsson P.G., Bergstrom M., Forsum U. Bacterial vaginosis. Transmission, role in genital tract infection and pregnancy outcome: an enigma. // APMIS. - 2005. - Vol. 113, N 4. - P. 233-245.
  11. McDonald H., Brocklehurst P., Parsons J. Antibiotics for treating bacterial vaginosis in pregnancy. // Cochrane Database Syst. Rev. - 2007. - N 1). - CD000362.
  12. Mead P.B. Epidemiology of bacterial vaginosis. // Am. J. Obstet. Gynec. - 2003. - Vol. 169, N 2. - P. 446-449.
  13. Riggs M.A., Klebanoff M.A. Treatment of vaginal infections to prevent preterm birth: a meta-analysis. // Clin. Obstet. Gynec. - 2004. - Vol. 47, N 4. -P. 796-807.

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