EFFICIENCY OF TREATMENT FOR MASTALGIA RESULTING FROM THE USE OF COMBINED ORAL CONTRACEPTIVES, VITEX AGNUS CASTUS EXTRACT


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Abstract

Objective. To study the efficacy of an extract from the plant Vitex agnus castus to relieve mastalgia caused by the use of combined oral contraceptives (COC) in two patient groups. Subjects and methods. A unicenter postmarketing uncontrolled comparative prospective, parallel group, randomized trial was conducted during 12 months (January 2009 to January 2010). A study group included 30 women receiving mastodynon, one tablet twice daily, for mastalgia resultingfrom COC use. A control group comprised 20 women taking vitamin E. The duration of treatment was 2 months; that of a follow-up after drug discontinuation was 3 months. Results. The digital analogue scale showed that after 2 months of treatment, pain intensity decreased from 4 to 1.6 and from 4.4 to 2.5 scores in the study and control groups, respectively. The percentage reduction in mastalgia intensity was more marked in the study group. Conclusion. Mastodinon prepared using the extract of Vitex agnus castus is an effective and safe drug in the treatment of mastalgia caused by COC use.

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About the authors

A. V LEDINA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: E- mail: ledina2003@oparina4.ru

V. N PRILEPSKAYA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

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