EFFICIENCY OF TREATMENT FOR MASTALGIA RESULTING FROM THE USE OF COMBINED ORAL CONTRACEPTIVES, VITEX AGNUS CASTUS EXTRACT
- Авторлар: LEDINA A.V1, PRILEPSKAYA V.N1
-
Мекемелер:
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
- Шығарылым: № 7-1 (2011)
- Беттер: 63-67
- Бөлім: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246622
- ID: 246622
Дәйексөз келтіру
Аннотация
Objective. To study the efficacy of an extract from the plant Vitex agnus castus to relieve mastalgia caused by the use of combined oral contraceptives (COC) in two patient groups. Subjects and methods. A unicenter postmarketing uncontrolled comparative prospective, parallel group, randomized trial was conducted during 12 months (January 2009 to January 2010). A study group included 30 women receiving mastodynon, one tablet twice daily, for mastalgia resultingfrom COC use. A control group comprised 20 women taking vitamin E. The duration of treatment was 2 months; that of a follow-up after drug discontinuation was 3 months. Results. The digital analogue scale showed that after 2 months of treatment, pain intensity decreased from 4 to 1.6 and from 4.4 to 2.5 scores in the study and control groups, respectively. The percentage reduction in mastalgia intensity was more marked in the study group. Conclusion. Mastodinon prepared using the extract of Vitex agnus castus is an effective and safe drug in the treatment of mastalgia caused by COC use.
Негізгі сөздер
Толық мәтін
![Рұқсат жабық](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_lock.png)
Авторлар туралы
A. LEDINA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
Email: E- mail: ledina2003@oparina4.ru
V. PRILEPSKAYA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
Әдебиет тізімі
- Руководство по контрацепции/Под ред. В.Н. Прилепской. - 2-е изд. - М.: МЕДпресс-информ, 2010.
- Abrams A.A. Use of vitamin E in chronic cystic mastitis (letter) // N. Engl.J. Med. -1965. - Vol. 272. - P. 1080-1081.
- Bayles B., Usatine R. Evening primrose oil // Am. Fam. Physician. - 2009. - Vol.80, № 12. - P. 1405-1408.
- BeLieu R.M. Mastodynia // Obstet. Gynecol. Clin. N. Am. -1994. - Vol. 21, № 3. - P. 461-477.
- Davies E.L. et al. The long-term course of mastalgia // J.Rou. Soc.Med. - 1998. - Vol. 91. - P. 462-464.
- Davies G.C. et al. Adverse events reported by postmenopausal women in controlled trials with raloxifene // Obstet. and Gynecol. - 1999. - Vol. 93.-P. 558-565.
- Faiz O., Fentiman I.S. Management of breast pain // Int. J. Clin.Pract. - 2000. - Vol. 54. - P.228-232.
- Halaska M. et al. Treatment of cyclical mastalgia with a solution contaning a Vitex agnus castus extract: results of a placebo-controlled double-blind study // The Breast.- 1999. - Vol. 8.- P. 175-181.
- Horner N.K., Lampe J.W. Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness // J.Am.Diet.Assoc. 2000. -Vol. 100. - P. 1368-1380.
- Hwang P.L. et al. Effect of oral contraceptives on serum prolactin: a longitudinal study in 126 normal premenopausal women // Clin. Endocrinol. (Oxford). - 1986 — Vol. 24, № 2. - P. 127-133.
- Ismail M.S., La Veccia C., Ron E., Franctschi S. et al. Elevated serum prolactin level with high-dose estrogen contraceptive pills // Eur.J.Contracept.Reprod. Hlth Care. - 1998. -Vol. 3, № 1. - P. 45-50.
- Kilicdag Е.В. et al. Fructus agni casti and bromocriptine for treatinent of hyperprolactinemia and mastalgia // Int. J. Gynaecol. Obstet. 2004. - Vol. 85. - P. 292-293.
- Klimberg V.S. Etiology and management of breast pain // Diseases of the breast/Eds J.R. Harris et al. - Philadelphia: Lippincott-Raven, 1996. - P. 99-106.
- Loch E.G. et al. Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus//J.Women's Hlth. - 2000. - Vol. 9. - P.315-320.
- Millett A.V., Dirbas F.M. Clinical management of breast pain: a review // Obstet. Gynecol. Surv. - 2002. - Vol. 57. -P. 451-461.
- Olawaiye A. et al. Mastalgia: a review of management // J.Reprod.Med. -2005. Vol. 50, № 12. - P. 933-939.
- Prilepskaya V.N. et al. Vitex agnus castus: Saccessful treatment of moderate to severe premenstrual syndrome // Maturitas. - 2006. - Vol. 55 (suppl.1). - P. 55-63.
- Pruthi S. et al.Vitamin E and evening primrose oil for management of cyclical mastalgia: a randomized pilot study // Altern.Med.Rev. - 2010. - Vol. 15, № 1.- P. 59-67.
- Singh B.B. et al. Incidence of premenstrual symptom and remedy usage: a national probability sample study // Altern. Ther. Hlth Med. - 1998. - Vol. 4. - P. 75-79.
- Smith R.L. et al. Evaluation and management of breast pain // Mayo Clin.Proc.-2004. - Vol. 79, № 3. - P. 353-372.
- Snowden E. U. et al.Opioid regulation ofpituitarygonadotropins and prolactin in women using oral contraceptives // Am.J. Obstet. Gynecol. - 1986. -Vol. 154, № 2. - P. 440-444.
- Wuttke W. et al. Chaste tree (Vitex agnus-castus)— pharmacology and clinical indications // Phytomedicine. -2003. - Vol. 10. - P. 348-357.
Қосымша файлдар
![](/img/style/loading.gif)