EXPERIENCE WITH EFFERENT METHODS USED IN THE TREATMENT OF SEVERE HYPERLIPIDEMIA IN A PREGNANT WOMAN


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Abstract

Objective. To evaluate the efficiency of using plasmapheresis (PA) and cascade plasma filtration (CPF) in a pregnant woman with severe hyperlipidemia. Subjects and methods. The paper describes a clinical observation of a female patient diagnosed as having 33—34-week pregnancy, chronic placental insufficiency, decompensated type 1 diabetes mellitus, diabetic micro- and macroangiopathy, hepatic steatosis, hyperlipidemia, and chronic pyelonephritis. She was treated with 3 PA sessions on a PSA-2 device (Haemonetics, USA) and 2 CPF sessions on a Cobe Spectra apparatus (Frezenius, Germany) with an Evaflux 5a filter (Kuraray, Japan). Clinical, biochemical, hemostasiological, and ultrasound studies were used. Results. There was a significant reduction in the lipid spectrum parameters: the levels of cholesterol, triglycerides, low-density lipoproteins, and thrombodynamic potential after a course of therapeutic PA and CPF. At 36 weeks gestation, the patient gave birth to a baby by cesarean section. The boy was alive, 47 cm in length, weighed 2359 g, with Apgar scores of 7/8. Conclusion. Efferent hemocorrection techniques should be considered as the methods of choice in treating pregnant women with obvious metabolic disturbances to prevent fatal pancreatitis and severe obstetric complications.

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About the authors

T. A FEDOROVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: tfedorova1@mail.ru
Moscow

O. V ROGACHEVSKY

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Moscow

N. V ORDZHONIKIDZE

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Moscow

O. N TKACHEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Moscow

I. V MITRYA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Moscow

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