PLACENTAL INSUFFICIENCY IN PREGNANT WOMEN WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA


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Abstract

Objective. To reveal on the basis of a prospective analysis the course of pregnancy, labor, delivery, and postpartum period and to study the immunohistochemical features of MMP expression in the elements of the placenta in cases of its insufficiency (PI) in pregnant women with undifferentiated connective tissue dysplasia (UDCT). Subject and methods. 300 pregnant women aged 18 to 45 years were examined. Group 1 (a study group) comprised 100 patients with the phenotypic signs of UDCT of 6 or scores and PI; Group 2 (a comparison group) consisted of 100 women with UDCT without the signs of PI; Group 3 (a control group) included 100 pregnant women without the signs of UDCT and PI. Their history data and the specific features of pregnancy, labor, delivery, and postpartum period were analyzed. The placentas underwent morphological examination, including immunohistochemical (MMP-2 and MMP-9) one. Results. Pregnancy in patients with UDCT was more commonly complicated by PI. The concurrence of PI and UDCT correlated with high somatic and gynecological morbidity rates. The immunohistochemical examination revealed a varying noticeable increase in the expression of MMP-2 and MMP-9 in the placental structures. Conclusion. Pregnant women with UDCT should be included into a group at high risk for PI.

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About the authors

N. E KAN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_kan@oparina4.ru

I. V KLIMANTSEV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: klimantsev-i@mail.ru

E. A DUBOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_dubova@oparina4.ru

E. Yu AMIRASLANOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: eldis@mail.ru

M. V SANNIKOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: rogach111@yandex.ru

O. A SERGUNINA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: magic2911@mail.ru

K. A PAVLOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: k_pavlov@oparina4.ru

A. I SHCHEGOLEV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: ashegolev@oparina4.ru

V. L TYUTYUNNIK

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_tioutiounnik@oparina4.ru

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