PROGNOSTIC CRITERIA FOR RECURRENT UTERINE LEIOMYOMA AFTER RECONSTRUCTIVE PLASTIC SURGERY


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Abstract

Objective. To study the clinical and morphological predictors of a recurrence of uterine leiomyoma in reproductiveaged women after reconstructive plastic surgery. Subjects and methods. Sixty reproductive-aged women, 30 of whom had undergone myomectomy for the first time and 30 had for recurrent uterine myoma, were examined. Clinical laboratory and morphological examinations were made; the immunohistochemical markers of proliferation (Ki-67), neoangiogenesis (VEGF), and invasion (MMP2, TIMP1) were investigated. Results. The authors revealed the morphological and immunohistochemical features of recurrent uterine leiomyoma and the presumptive sources of the recurrent tumor as microscopic myomas, perivascular growth areas, and scars after myomectomy. Conclusion. High TIMP-1 levels in the leiomyoma inhibit its growth and prolong time to its recurrence.

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About the authors

Yu. E KARAVAYEV

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia

Email: byraya@mail.ru
Depatment of Reproductive Medicine and Surgery, Faculty of Postgraduate Education

S. I ASKOLSKAYA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: s_askolskaya@oparina4.ru

E. A KOGAN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kogan@oparina4.ru

K. N ARSLANYAN

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia

Email: karslanyan@mail.ru
Depatment of Reproductive Medicine and Surgery, Faculty of Postgraduate Education

P. N BURYKINA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: p_burykina@oparina4.ru

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