COMPARATIVE ASSESSMENT OF METHODS FOR DIAGNOSIS OF THE ENDOMETRIUM IN POSTMENOPAUSAL PATIENTS WITH BREAST CANCER TAKING TAMOXIFEN
- Authors: MAMIKONYAN I.O1, SARKISOV S.E1, BOIKO M.A1, GYURHYAN S.A1, SATTAROV S.N1
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Affiliations:
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
- Issue: No 10 (2013)
- Pages: 59-62
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247047
- ID: 247047
Cite item
Abstract
Objective. To comparatively assess diagnostic methods and endometrial changes by ultrasonography (USG) and hysteroscopy in postmenopausal patients taking tamoxifen. Subject and methods. One hundred tamoxifen-treated women with breast cancer who had the endometrium more than 5 mm thick were examined using USG. All the examinees were postmenopausal. The study evaluated the sensitivity, specificity, accuracy, and diagnostic efficiency of USG and hysteroscopy. Results. Ultrasound scanning revealed the following abnormalities: 38 cases of endometrial polyps, 11 cases of endometrial polyps concurrent with endometrial hyperplasia, and 51 cases of endometrial hyperplasia. Endometrial polyps were the most common diagnosis (in 59 cases of the 100 cases). Conclusion. The sensitivity and specificity of USG were 89.3 and 66.6%, respectively. Hysteroscopy had a very high sensitivity (96.97%) and specificity (91.2%).
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About the authors
I. O MAMIKONYAN
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: irulikjan@rambler.ru
Moscow
S. E SARKISOV
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of RussiaMoscow
M. A BOIKO
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of RussiaMoscow
S. A GYURHYAN
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of RussiaMoscow
Sh. N SATTAROV
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of RussiaMoscow
References
- Jones M.E., van Leeuwen F.E., Hoogendoorn W.E., Mourits M.J., Hollema H., van Boven H. et al. Endometrial cancer survival after breast cancer in relation to tamoxifen treatment: pooled results from three countries. Breast Cancer Res. 2012; 14(3): R91.
- Chia S.K., Wolff A.C. With maturity comes confidence: EBCTCG tamoxifen update. Lancet. 2011; 378( 9793): 747—9.
- Schmidt D. Changes in the endometrium after tamoxifen therapy. Pathology. 2006; 27(1): 27—32.
- Runowicz C.D., Costantino J.P., Wickerham D.L., Cecchini R.S., Cronin W.M., Ford L.G. et al. Gynecologic conditions in participants in the NSABP breast cancer prevention study of tamoxifen and raloxifene (STAR). Am J. Obstet. Gynecol. 2011; 205(6): 535; e1—5.
- Pérez-Medina T., Salazar F.J., San-Frutos L., Ríos M., Jiménez J.S., Troyano J. et al. Hysteroscopic dynamic assessment of the endometrium in patients treated with long-term tamoxifen. J. Minim. Invasive Gynecol. 2011; 18(3): 349—54.
- Negoiţă M., Terinte C., Mihailovici M.S. Tamoxifen and endometrial pathology. Rev. Med. Chir. Soc. Med. Nat. Iasi. 2010; 114(4): 1114—7.
- Атабекова Л.А., Виноградова Н.М., Шарапова Е.И., Бурков С.Г. Значение эхографии в комплексной диагностике гиперпластических процессов эндометрия в условиях поликлиники. SonoAce-Ultrasound. 2006; 14: 29—34.
- Tsikouras P., Liberis V., Galazios G., Grapsas X., Kantari P., Papageorgiou S. et al. TV sonographic assessment in postmenopausal women with bleeding. Eur. J. Gynaecol. Oncol. 2008; 29(1): 67—71.
- Yela D.A., Hidalgo S.R., Pereira K.C., Gabiatti J.R., Monteiro I.M. Comparative study of transvaginal sonography and outpatient hysteroscopy for the detection of intrauterine diseases. Acta Med. Port. 2011; 24(Suppl. 2): 65—70.
- Мамаев А.Н. Основы медицинской статистики. М.: Практическая медицина; 2011. 128 с.
- Dibi R.P., Zettler C.G., Pessini S.A., Ayub A.V., de Almeida S.B., da Silveira G.P. Tamoxifen use and endometrial lesions: hysteroscopic, histological, and immunohistochemical findings in postmenopausal women with breast cancer. Menopause. 2009; 16(2): 293—300.
- Gao W.L., Zhang L.P., Feng L.M. Comparative study of transvaginal ultrasonographic and diagnostic hysteroscopic findings in postmenopausal breast cancer patients treated with tamoxifen. Chin. Med. J. (Engl.). 2011; 124(15): 2335—9.
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