PERSONALIZED APPROACH TO USING MIFEPRISTONE IN PATIENTS WITH UTERINE MYOMA


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Abstract

Objective. To study the gene expression of steroid receptors (mER, PR-A, GR, and AR) in the blood mononuclear cells from patients with uterine myoma in relation to the efficiency of therapy with mifepristone. Subjects and methods. The investigation enrolled 50 patients whose myomas were smaller than a 12 week pregnancy (interstitial, interstitial-subserous nodules). Oral mifepristone (gynestril, Stada) 50 mg was given daily for 3 months. The gene expression of the receptors in the patients’ mononuclear cell fraction was determined by RT-PCR. Results. 5-fold greater gene expression of nuclear glucocorticoid receptors (p = 0.02) was seen in patients with no mifepristone effect on myoma sizes. Conclusion. The receptor profile of the mononuclear cell fraction may serve as indirect prognostic sign of the efficiency and expediency of using mifepristone in the therapy of patients with uterine myoma.

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About the authors

Elena Nikolaevna Kareva

Academician P.V. Sergeev Department of Molecular Pharmacology and Radiobiology, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: elenakareva@mail.ru
DM, Professor of Academician Moscow 117997, Ostrovitianov str. 1, Russia

Lamara Khanbalalovna Bekhbudova

Academician P.V. Sergeev Department of Molecular Pharmacology and Radiobiology, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: Lamarabekh@gmail.com
Assistant of Department of Pharmacology Pediatric Faculty Moscow 117997, Ostrovitianov str. 1, Russia

Olga Sergeevna Gorenkova

Moscow Regional Research Institute of Obstetrics and Gynecology

Email: olga-gore@mail.ru
Candidate of Medical Science, gynecologist and endocrinologist Moscow 101000, Pokrovka str. 22a, Russia

Tatiana Evgen'evna Samoilova

N.I. Pirogov National Medical Surgical Center

Email: tesamoylova@mail.ru
MD, Professor of Department of Women’s Diseases and Reproductive Health Moscow 105203, Nizhnyaya Pervomayskaya str. 70, Russia

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