CENTRAL VENOUS CATHETER COLONIZATION IN INTENSIVE CARE UNIT NEONATES: RISK FACTORS AND CLINICAL SIGNIFICANCE


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Abstract

Objective. To determine the factors influencing the colonization of a central venous catheter (CVC) and the clinical status of intensive care unit neonates, whose CVC is colonized with microorganisms. Subjects and methods. The neonates were divided into two groups: 1) neonates, whose catheter was colonized with opportunistic microorganisms and 2) those whose catheter after its removal showed no growth of microorganisms. The investigation assessed whether CVC colonization was present or absent and microbial species were identified. Results. 165 results of CVC cultures were analyzed in 112 newborns. The investigation has indicated that the most critical factor in increasing the risk for contamination of a CVC is the time of its insertion. The use of a CVC during a week or longer does not increase the rate of microbial colonization. Conclusion. The findings may lead to the conclusion that the prevention of catheter-related infections in neonates should lie in the selection of an adequate antiseptic for the processing of a surgical field, its adequate exposure and technique for aseptic CVC insertion by a medical staff.

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About the authors

Lyudmila A. Lyubasovskaya

Email: labmik@yandex.ru
PhD, Head of the clinical pharmacology unit, Department of clinical pharmacology and microbiology, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Tatiana V. Priputnevich

Email: priput1@gmail.com
PhD, Doctor of Science, Head of the Department of clinical pharmacology and microbiology, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

Irina V. Nikitina

Email: i_nikitina@oparina4.ru
PhD, Doctor of the Department of Resuscitation and Intensive Care of Newborns, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

Maria A. Kornienko

Email: kornienkomariya@gmail.com
Junior researcher of the Federal Research Clinical Center of Physicochemical Medicine, Federal Biomedical Agency of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Julia V. Rodchenko

Email: y_rodchenko@oparina4.ru
Bacteriologist in the Microbiology Laboratory, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Alexey B. Gordeev

Email: gordeew@vega.protres.ru
PhD, Researcher in the Microbiology Laboratory, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Oleg V. Ionov

Email: Dr.ionov@hotmail.com
Ph.D., Head of the intensive care department of neonatology and pediatrics, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Victor V. Zubkov

Email: v_zubkov@oparina4.ru
PhD, Doctor of Science, Head of the Department of Neonatology and Pediatrics, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

Elena N. Ilina

Email: ilinaen@gmail.com
PhD, Doctor of Science, RAS professor, Deputy director for science of the Federal Research Clinical Center of Physicochemical Medicine, Federal Biomedical Agency of Russia. 119435, Russia, Moscow, Malaya Pirogovskaya str. 1a

Dmitriy V. Dubodelov

Email: d_dubodelov@oparina4.ru
PhD, Senior Researcher in the Microbiology Laboratory, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

Anastasia A. Safanovskaya

Email: safanana@bk.ru
Resident medical practitioner of the Department of Resuscitation and Intensive Care of Newborns, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

Alina R. Melkumyan

Email: alinamelkumyan@yandex.ru
PhD, Researcher in the Microbiology Laboratory, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

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