INTERFERON INDUCERS IN THE COMBINATION THERAPY OF UTERINE CERVICAL DISEASES IN PERSISTENT HUMAN PAPILLOMAVIRUS INFECTION


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Background. Despite the ability to visualize the type of precancer and its long period and sufficiently sensitive, specific, and inexpensive screening tests (cytology testing and determination of human papillomavirus ((HPV) with the possibility of combining them in liquid technology), the incidence of invasive cancer increases and the neglect of the latter is not reduced. Objective. To improve therapy for a treatment outcome for uterine cervical diseases with persistent HPV infection. Subjects and methods. To solve the set tasks, the investigators examined 50 patients with cervical diseases and persistent HPV infection (retrospective medical history data, Pap test, HPV testing, extended colposcopy, cervicoscopy, radiosurgical conization of the cervix with subsequent morphological examination). Results. The proposed package of measures, based on antiviral therapy with allokin-alpha and on a differentiated approach to choosing a surgical treatment, could obtain the maximum positive treatment result. The complete and incomplete effects after combination treatment were observed in 94 and 6% of the women, respectively. Conclusion. Thus, the proposed package of measures, based on antiviral therapy with allokin-alpha and a differentiated approach to choosing a surgical treatment, could obtain the maximum positive treatment result.

Full Text

Restricted Access

About the authors

Victor Ye. Radzinsky

Email: radzinsky@mail.ru
Corresponding Member. RAMS, MD, professor, head of the department of Obstetrics and Gynecology with the course of perinatology, Peoples’ Friendship University of Russia. 117198, Russia, Moscow, Miklukho-Maklaya str. 6

Irina M. Ordiyants

Email: ordiyantc@mail.ru
Professor of the Department of Obstetrics and Gynecology with the course of Perinatology, Peoples’ Friendship University of Russia. 117198, Russia, Moscow, Miklukho-Maklaya str. 6

Natalia Vladimirovna Buyanova

Email: bnv.doc@mail.ru
the competitor of the Department of Obstetrics and Gynecology with the course of Perinatology, Peoples’ Friendship University of Russia. 117198, Russia, Moscow, Miklukho-Maklaya str. 6

Evgeniy V. Zykov

Email: yevgeny_zykov@hotmail.com
post-graduate student of the Department of Obstetrics and Gynecology with the course of perinatology, Peoples’ Friendship University of Russia. 117198, Russia, Moscow, Miklukho-Maklaya str. 6

References

  1. Аминодова И.П., Джалалова П.М., Лапочкина Н.П., Кутинова Е.Г. Реабилитация репродуктивной функции у пациенток с заболеваниями шейки матки. Научный поиск. 2015; 2.2: 5-7. [Aminodova I.P., Dzhalalova P.M., Lapochkina N.P., Kutinova E.G. Rehabilitation of reproductive function in patients with cervical disease. Nauchnyiy poisk. 2015; 2.2: 5-7. (in Russian)]
  2. АшрафянЛ.А., Бабаева Н.А., Антонова И.Б., Ивашина С.В., Моцкобили Т.А., Алешикова О.И., Кузнецов И.Н. Папилломавирусная инфекция и нарушение баланса эстрогенных метаболитов как фактора риска развития рака органов женской репродуктивной системы. Онкология. Журнал им. П.А. Герцена. 2015; 4(1): 5-12. [Ashrafyan L.A., Babaeva N.A., Antonova I.B., Ivashina S.V., Motskobili T.A., Aleshikova O.I., Kuznetsov I.N. Papillomavirus infection and imbalance of estrogen metabolites as a risk factor for cancer of the female reproductive system. Onkologiya. Zhurnal im. P.A. Gertsena. 2015; 4(1): 5-12. (in Russian)]
  3. Данькина И.А., Джеломанова С.А., Данькина В.В., Чистяков А.А. Влияние различных факторов на возникновение заболеваний шейки матки у пациенток репродуктивного возраста. В кн.: Актуальные проблемы медицины (материалы ежегодной итоговой научно-практической конференции. 26-27 января 2017г. г. Гродно). 2017: 250-4. [Dankina I.A., Dzhelomanova S.A., Dankina V.V., Chistyakov A.A. The influence of various factors on the occurrence of cervical diseases in patients of reproductive age. In: Actual problems of medicine (materials of the annual final scientific and practical conference, January 26-27, 2017, Grodno). 2017: 250-4. (in Russian)]
  4. Радзинский В.Е., Ордиянц И.М., Буянова Н.В., Побединская О.С. Тактика ведения пациенток с заболеваниями шейки матки при персистирующей ВПЧ-инфекции: возможности комбинированного лечения. Гинекология. 2014; 16(6): 12-5. [Radzinskiy V.E., Ordiyants I.M., Buyanova N.V., Pobedinskaya O.S. Tactics of management of patients with cervical disease with persistent HPV infection: the possibility of combined treatment. Ginekologiya. 2014; 16(6): 12-5. (in Russian)]
  5. Короленкова Л.И. Правомочна ли иммуномодулирующая терапия при Cin? Российский биотерапевтический журнал. 2013; 12(2): 45-45a. [Korolenkova L.I. Is immunomodulatory therapy eligible for Cin? Russian Biotherapeutic Journal. 2013; 12(2): 45-45a. (in Russian)]
  6. Короленкова Л.И. Клинико-морфологическая концепция возникновения и течения тяжелых Cin. Клиническая лабораторная диагностика. 2014; 59(6): 18-22. [Korolenkova L.I. Clinical and morphological conception of the onset and course of severe Cin. Klinicheskaya laboratornaya diagnostika. 2014; 59(6): 18-22. (in Russian)]
  7. Роговская С.И., Липова Е.В. Шейка матки, влагалище, вульва. М.: Status Presens; 2014. [Rogovskaya S.I., Lipova E.V. Cervix, vagina, vulva. Moscow: Status Presens; 2014. (in Russian)]
  8. Львова С.А. Значение цитологического исследования для диагностики заболеваний шейки матки. В кн.: В мире исследований. Материалы II Международного форума студенческой и учащейся молодежи. Нечаев М.П., ред. 2017: 85-9. [Lvova S.A. The importance of cytological research for the diagnosis of cervical disease. In: In the world of research. Materials of the II International Forum of Student and Student Youth. Nechaev M.P., ed. 2017: 85-9. (in Russian)]

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2018 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies