Features of serum lipidome in pregnant women with fetal macrosomia and a concurrence of macrosomia with gestational diabetes mellitus


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Abstract

Objective. To elaborate an analytical approach to predicting fetal macrosomia (FM) on the basis of maternal serum lipidome analysis. Subjects and methods. A prospective cohort study enrolled 120pregnant women with FM and gestational diabetes mellitus (GDM). Serum lipid levels were analyzed by mass spectrometry. Results. The best prognostic models were obtained at 11-14 and 24-28 weeks’ gestation in women with GDM (the sensitivity and specificity were 0.91/0.96 and 0.93/0.96, respectively), at 11-14 weeks in the entire group and in patients without GDM (0.85/0.91 and 0.93/0.92). The findings make it possible to predict FM according to the presence or absence of GDM. Conclusion. The introduction of the developed models into obstetric practice will become a new tool for assessing the risk for FM, which will be able to reduce its rate and to improve maternal and perinatal outcomes.

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About the authors

Victoriya A. Odinokova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_odinokova@oparina4.ru

Vitaliy V. Chagovets

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: vvchagovets@gmail.com

Roman G. Shmakov

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: r_shmakov@oparina4.ru

Nataliya L. Starodubtseva

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_starodubtseva@oparina4.ru

Dinara Failievna Salimova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: Salimova.1993@mail.ru

Alexey S. Kononikhin

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: konoleha@yandex.ru

Vladimir E. Frankevich

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_frankevich@oparina4.ru

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