CARBOXYTHERAPY OF GENITOURINARY SYNDROME OF MENOPAUSE


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Abstract

Genitourinary syndrome of menopause is one of the challenging problems encountered by gynecologists. Management of this patient category is a complex, lengthy and complicated endeavor. Aim. To investigate the clinical effectiveness of ultrasound-guided carboxytherapy as a conservative treatment for genitourinary syndrome of menopause. Materials and methods. The present prospective clinical study comprised 35 postmenopausal women with mean age 52.9 (3.4) years, duration of postmenopause 3.27(2.4) years, and mean duration of genitourinary syndrome of menopause 2.9 (0.9) years. Carboxytherapy was performed using a VENUSIAN CO2 Therapy device delivered in four (3.5) 5 min weekly sessions. Ultrasonography was carried out using DC-8, Resona-7 (Mindray, China), Logiq E9 (GE, USA) ultrasound scanners with linear 7.5-15 MHz probes. The analyzed parameters included the vaginal health index (VHI), vaginal epithelium maturation index (VEMI), and the results of the VSQ questionnaire. Results. Compared with baseline values, VHI increased by 30% from 10.4 (5.2) to 17.8 (4.9) (p<0.001); VEMI increased from 53.7 (3.9) to 77.8 (9.9) (p<0.001). Vaginal pH level changedfrom 6.0 (0.9) to 4.6 (0.7) (p<0.001). VSQ scores improved from 11.7 (4.8) to 5.9 (2.5). Frequency and intensity of vulvovaginal atrophy symptoms reduced by almost 50%, which indicates high effectiveness of carboxytherapy (p<0.001). Conclusion. The study findings suggest that ultrasound-guided carboxytherapy is an effective, acceptable, and safe treatment option for genitourinary syndrome of menopause.

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About the authors

Ayna S. SAIDOVA

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: asekova14@yandex.ru
Ph.D., Obstetrician-Gynecologist at the Department of Aesthetic Gynecology and Rehabilitation Moscow, Russia

Alexandr N. SENCHA

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: senchavyatka@mail.ru
Dr.Med.Sci., Head of the Department of Diagnostic Imaging Moscow, Russia

Inna A. APOLIKHINA

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia; I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia (Sechenov University)

Email: apolikhina@inbox.ru
Dr.Med.Sci., Professor, Head of the Department of Aesthetic Gynecology and Rehabilitation, V.I. Kulakov NMRC for OG&P of Minzdrav of Russia; Professor at the Department of Obstetrics, Gynecology, Perinatology and Reproductology, I.M. Sechenov First MSMU of Minzdrav of Russia (Sechenov University). Moscow, Russia

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