WIF1 gene methylation in endometrial pathology
- Authors: Ashrafyan L.A.1, Kiselev V.I.1, Chernukha G.E.1, Ivanov I.A.1, Poloznikov A.A.2
-
Affiliations:
- V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- National Medical Radiology Research Centre, Ministry of Health of Russia
- Issue: No 12 (2020)
- Pages: 122-128
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/249075
- DOI: https://doi.org/10.18565/aig.2020.12.122-128
- ID: 249075
Cite item
Abstract
Full Text
![Restricted Access](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_lock.png)
About the authors
Lev A. Ashrafyan
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: l_ashrafyan@oparina4.ru
Academician of the RAS, Dr. Med. Sci., Professor, Director of the Institute of Oncogynecology and Mammology
Vsevolod I. Kiselev
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: vkis10@mail.ru
Dr. Bio. Sci., Corr. Member of the RAS, Deputy Director of the Institute of Gynecoloigy and Mammology
Galina E. Chernukha
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: g_chernukha@oparina4.ru
Dr. Med. Sci., Professor
Ilya A. Ivanov
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: doctor.i.ivanov@yandex.ru
Postgraduate Student at the Department of Gynecological Endocrinology
Andrey A. Poloznikov
National Medical Radiology Research Centre, Ministry of Health of Russia
Email: andrey.poloznikov@nmicr.ru
PhD. (chem. Sci.)., Deputy Director for Science
References
- Clark T.J., Stevenson H. Endometrial Polyps and Abnormal Uterine Bleeding (AUB-P): What is the relationship; how are they diagnosed and how are they treated? Best Pract. Res. Clin. Obstet. Gynaecol. 2017; 40: 89-104. https:// dx.doi.org/10.1016/j.bpobgyn.2016.09.005.
- Чернуха Г.Е., Асатурова А.В., Иванов И.А., Думановская М.Р. Структура патологии эндометрия в различные возрастные периоды. Акушерство и гинекология. 2018; 8: 129-34. https://dx.doi.org/10.18565/ aig.2018.8.129-134. [Chernukha G.E., Asaturova A.V., Ivanov I.A., Dumanovskaya M.R. Endometrial lesion’s pattern in different age groups. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; 8: 129-34. (in Russian)].
- Capmas P., Pourcelot A.G., Giral E., Fedida D., Fernandez H. Office hysteroscopy: A report of 2402 cases. J. Gynecol. Obstet. Biol. Reprod. (Paris). 2016; 45(5): 445-50. https://dx.doi.org/10.1016/j.jgyn.2016.02.007.
- Cooper N., Barton P., Breijer M., Caffrey O., Opmeer B.C., Timmermans A. et al. Cost-effectiveness of diagnostic strategies for the management of abnormal uterine bleeding (heavy menstrual bleeding and post-menopausal bleeding): a decision analysis. Health Technol. Assess. 2014; 18(24): 1-201, v-vi. https:// dx.doi.org/10.3310/hta18240.
- Tanos V., Berry K.E., Seikkula J., Abi Raad E., Stavroulis A., Sleiman Z. et al. The management of polyps in female reproductive organs. Int. J. Surg. 2017; 43: 7-16. https://dx.doi.org/10.1016/j.ijsu.2017.05.012.
- Gon S., Kundu T., Mallick D., Ghosh G. A study on histopathological patterns of endometrium in different types of abnormal uterine bleeding among peri and postmenopausal women. J. Dent. Med. Sci. (IOSR-JDMS). 2016; 15(9): 106-11.
- Xie J., Zhang Y., Hu X., Lv R., Xiao D., Jiang L., Bao Q. Norcantharidin inhibits Wnt signal pathway via promoter demethylation of WIF 1 in human non small cell lung cancer. Med. Oncol. 2015; 32(5): 145. https://dx.doi.org/10.1007/ s12032-015-0592-0.
- Есенеева Ф.М., Шалаев О.Н., Оразмурадов А.А., Радзинский В.Е., Куулар А.А., Киселев В.И., Салимова Л.Я. WNT-сигнальный путь при миоме матки. Мать и дитя в Кузбассе. 2017; 2: 33-8. [Eseneeva F.M., Shalaev O.N., Radzinskiy V.E., Kiselev V.I. et al. WNT signal way in myomautery. Mother and Child in Kuzbass. 2017; 2: 33-8. (in Russian)].
- Киселев В.И., Муйжнек Е.Л., Ашрафян Л.А., Сухих Г.Т. Эпигенетика в гинекологии и онкогинекологии: WIF реальность. Акушерство и гинекология: новости, мнения, обучение. 2018; 1: 18-26.
- Kiewisz J., Wasniewski T., Kmiec Z. Participation of WNT and [3-catenin in physiological and pathological endometrial changes: association with angiogenesis. Biomed. Res. Int. 2015; 2015: 854056. https://dx.doi. org/10.1155/2015/854056.
- Domenico M., Santoro A, Ricciardi C., Iaccarino M., Iaccarino S., Freda M. et al. Epigenetic fingerprint in endometrial carcinogenesis: the hypothesis of a uterine field cancerization. Cancer Biol. Ther. 2011; 12(5): 447-57. https://dx.doi. org/10.4161/cbt.12.5.15963.
- Deng X., Hou C., Wang H., Liang T., Zhu L. Hypermethylation of WIF1 and its inhibitory role in the tumor growth of endometrial adenocarcinoma. Mol. Med. Rep. 2017; 16(5): 7497-503. https://dx.doi.org/10.3892/ mmr.2017.7564.
- C'ухих Г.Т., Ашрафян Л.А., Байрамова Г.Р., Бабкина И.О., Чернова В.Ф., Осипьянц А.И., Королькова А.И., Полозников А.А., Асфарова Г.Р., Муллабаева С.М., Коган Е.А., Муйжнек Е.Л., Друх В.М., Киселев В.И. Метилирование гена WIF-1 при цервикальных плоскоклеточных интра-эпителиальных поражениях. Акушерство и гинекология. 2017; 5: 114-23. https://dx.doi.org/10.18565/aig.2017.5.114-23.
- Yee D., Tang Y., Li X. The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition. Mol. Cancer. 2010; 9: 162. https://dx.doi.org/10.1186/1476-4598-9-162.
- van der Horst P., Wang Y., Vandenput I., KUhne L., Ewing PC, van Ijcken W.F. et al. Progesterone inhibits epithelial-to-mesenchymal transition in endometrial cancer. PLoS One. 2012; 7(1): e30840. https://dx.doi.org/10.1371/journal. pone.0030840.
- Xihai W., Jilan M., Jingyan J., Fangmei L. Analysis of methylation profiling data of hyperplasia and primary and metastatic endometrial cancers. Eur. J. Obstet. Gynecol. Reprod. Biol. 2017; 217: 161-6. https://dx.doi.org/10.1016/ j.ejogrb.2017.08.036.
- Tao M., Freudenheim L. DNA methylation in endometrial cancer. Department of Social and Preventive Medicine. Epigenetics. 2010; 5(6): 491-8.
- Klutstein M., Nejman D., Greenfield R., Cedar H. DNA methylation in cancer and aging. Cancer Res. 2016; 76(12): 3446-50. https://dx.doi.org/10.1158/ 0008-5472.CAN-15-3278.
- O 'Hagan H.M., Wang W., Sen S., Destefano Shields C., Lee S.S., Zhang Y.W. et al. Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands. Cancer Cell. 2011; 20(5): 606-19. https://dx.doi.org/10.1016/ j.ccr.2011.09.012.
- Niwa T., Ushijima T. Induction of epigenetic alterations by chronic inflammation and its significance on carcinogenesis. Adv. Genet. 2010; 71: 41-56. https:// dx.doi.org/10.1016/B978-0-12-380864-6.00002-X.
- Feng M., Zhang T., Ma H. Progesterone ameliorates the endometrial polyp by modulating the signaling pathway of Wnt and [3-catenin via regulating the expression of H19 and miR-152. J. Cell. Biochem. 2019; 120(6): 10164-74. https://dx.doi.org/10.1002/jcb.28301.
- Marichereda V.G., Bykovа N.A., Bubnov V.V., Manasova G.S., Moskalenko T.Y., Volyanska A.G. et al. The analysis of methylation of DNA promoter of SFRP2 gene in patients with hyperplastic processes of the endometrium. Exp. Oncol. 2018; 40(2): 109-13.
- Goad J., Ko Y.A., Kumar M., Jamaluddin M.F.B., Tanwar P.S. Oestrogen fuels the growth of endometrial hyperplastic lesions initiated by overactive Wnt/P-catenin signalling. Carcinogenesis. 2018; 39(9): 1105-16. https://dx.doi.org/10.1093/ carcin/bgy079.
- Indraccolo U., Di Iorio R., Matteo M., Corona G., Greco P., Indraccolo S.R. The pathogenesis of endometrial polyps: a systematic semi-quantitative review. Eur. J. Gynaecol. Oncol. 2013; 34(1): 5-22.
- Carvalho F.M., Aguiar F.N., Tomioka R., de Oliveira R.M., Frantz N., Ueno J. Functional endometrial polyps in infertile asymptomatic patients: a possible evolution of vascular changes secondary to endometritis. Eur. J. Obstet. Gynecol. Reprod. Biol. 2013; 170(1): 152-6. https://dx.doi.org/10.1016/j. ejogrb.2013.05.012.
- Zhu Y., Du M., Yi L., Liu Z., Gong G., Tang X. CD4+ T cell imbalance is associated with recurrent endometrial polyps. Clin. Exp. Pharmacol. Physiol. 2018; 45(6): 507-13. https://dx.doi.org/10.1111/ 1440-1681.12913.
- Cicinelli E., Bettocchi S. Chronic endometritis: a common disease hidden behind endometrial polyps in pre-menopausal women. First evidence from a case-control study. J. Minim. Invasive Gynecol. 2019; 26(7): 1346-50. https:// dx.doi.org/10.1016/j.jmig.2019.01.012.
- Sanderson P., Critchley H., Williams A., Arends M.J., Saunders P.T. New concepts for an old problem: the diagnosis of endometrial hyperplasia. Hum. Reprod. Update. 2017; 23(2): 232-54. https://dx.doi.org/10.1093/humupd/ dmw042.
- Erkanli S., Bolat F., Kayaselcuk F., Demirhan B., Kuscu E. COX-2 and survivin are overexpressed and positively correlated in endometrial carcinoma. Gynecol. Oncol. 2007; 104(2): 320-5. https://dx.doi.org/10.1016/ j.ygyno.2006.08.044.
- Шешукова Н.А., Макаров И.О., Овсянникова Т.В. Гиперпластические процессы эндометрия: особенности пролиферативной активности при сочетании с хроническим эндометритом. Акушерство, гинекология и репродукция. 2011; 5(3): 10-15
Supplementary files
![](/img/style/loading.gif)