Favorable outcome of managing a pregnant woman with epidermolytic drug syndrome
- Authors: Tezikov Y.V.1, Tezikova T.A.2, Lipatov I.S.1, Shmakov R.G.3, Rakitina V.N.2, Mishina E.A.2
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Affiliations:
- Samara State Medical University, Ministry of Health of Russia
- V.D. Seredavin Samara Regional Clinical Hospital
- Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
- Issue: No 4 (2021)
- Pages: 158-164
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/249285
- DOI: https://doi.org/10.18565/aig.2021.4.158-164
- ID: 249285
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Abstract
Background. Epidermolytic drug reactions (EDR) in pregnant women have been described in single cases. The mortality rates for Stevens-Johnson syndrome and Lyell syndrome are 5.0- 7.5% and 30-70%, respectively. The proven association of the syndromes with drugs, viral diseases necessitates systematization of practical knowledge, which is relevant for the management of pregnant women and the elaboration of obstetric tactics. Case report. The clinical case of a pregnant woman with EDR demonstrates diff iculties in the differential diagnosis of Stevens-Johnson syndrome with transformation into Lyell syndrome with hemorrhagic vasculitis, toxicoderma, psoriasis, and a favorable gestational outcome during medical treatment for a large lesion area. The management of pregnant near miss cases required an interdisciplinary approach. The capabilities of telemedicine are used to make consultations by specialists. Conclusion. The accumulation of clinical experience and the choice of medical policy with a high level of evidence will undoubtedly allow avoiding maternal and perinatal critical conditions in the medical management of pregnant women with EDR.
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About the authors
Yurii V. Tezikov
Samara State Medical University, Ministry of Health of Russia
Email: yra.75@inbox.ru
MD, professor, Head of the Department of Obstetrics and Gynecology No.l
Tatiana A. Tezikova
V.D. Seredavin Samara Regional Clinical Hospital
Email: t-tezikova@mail.ru
Deputy Chief Physician for Obstetrics and Gynecology, Perinatal Center
Igor S. Lipatov
Samara State Medical University, Ministry of Health of Russia
Email: i.lipatoff20i2@yandex.ru
MD, professor, professor of the Department of Obstetrics and Gynecology No. I
Roman G. Shmakov
Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: r_shmakov@oparina.ru
MD, professor of the RAS, director of the Institute of Obstetrics
Valentina N. Rakitina
V.D. Seredavin Samara Regional Clinical Hospital
Email: t-tezikova@mail.ru
Head of Obstetric Department, Perinatal Center
Elena A. Mishina
V.D. Seredavin Samara Regional Clinical Hospital
Email: t-tezikova@mail.ru
Head of Anesthesiology and Intensive Care Department, Perinatal Center
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