Undifferentiated connective tissue dysplasia in women of reproductive age: cross sectional study

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Abstract

Objective: The aim of the study was to identify the prevalence of undifferentiated connective tissue dysplasia (UCTD) and association with a burdened obstetric history (BOH) of miscarriage in women of reproductive age, who residents of the Minsk region (the Republic of Belarus).

Materials and methods: From March 2022 to May 2022, a cross sectional study was carried out. It included 384 women aged 22–46 years, who were admitted to healthcare facility “Maternity hospital of the Minsk region” (the Republic of Belarus) with purpose of pregravid preparation. According to the results of comprehensive evaluation, the presence of UCTD, prevalence of clinical signs of UCTD and association of UCTD with BOH were identified.

Results: Among women of reproductive age in the Minsk region, UCTD was identified in 35.7% of women (95% CI 30.9–40.7). In the group of patients with UCTD, BOH of miscarriage was 3.5 times more often – in 19/137(13,4%) women compared to women who had no UCTD – in 11/247 (4.5%); OR 3.5 [1.6; 7.5].

Conclusion: High prevalence of UCTD and association with BOH of miscarriage was identified in women of reproductive age, who are residents of the Minsk region. Based on the results of this study, formation of a comprehensive program for identifying UCTD at the stage of pregravid preparation needs to be determined.

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About the authors

Elena N. Grudnitskaya

Institute of Advanced Training and Retraining of Healthcare Personnel, Belarusian State Medical University

Author for correspondence.
Email: grudnickaja@mail.ru
ORCID iD: 0009-0003-5268-4029

PhD, Associate Professor, Associate Professor of the Department of Obstetrics and Gynecology

Belarus, Minsk

Larysa M. Nebyshynets

Institute of Advanced Training and Retraining of Healthcare Personnel, Belarusian State Medical University

Email: larisa_minsk08@mail.ru
ORCID iD: 0009-0002-3966-4173

PhD, Associate Professor, Head of the Department of Obstetrics and Gynecology

Belarus, Minsk

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