Undifferentiated connective tissue dysplasia in women of reproductive age: cross sectional study

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Objective: The aim of the study was to identify the prevalence of undifferentiated connective tissue dysplasia (UCTD) and association with a burdened obstetric history (BOH) of miscarriage in women of reproductive age, who residents of the Minsk region (the Republic of Belarus).

Materials and methods: From March 2022 to May 2022, a cross sectional study was carried out. It included 384 women aged 22–46 years, who were admitted to healthcare facility “Maternity hospital of the Minsk region” (the Republic of Belarus) with purpose of pregravid preparation. According to the results of comprehensive evaluation, the presence of UCTD, prevalence of clinical signs of UCTD and association of UCTD with BOH were identified.

Results: Among women of reproductive age in the Minsk region, UCTD was identified in 35.7% of women (95% CI 30.9–40.7). In the group of patients with UCTD, BOH of miscarriage was 3.5 times more often – in 19/137(13,4%) women compared to women who had no UCTD – in 11/247 (4.5%); OR 3.5 [1.6; 7.5].

Conclusion: High prevalence of UCTD and association with BOH of miscarriage was identified in women of reproductive age, who are residents of the Minsk region. Based on the results of this study, formation of a comprehensive program for identifying UCTD at the stage of pregravid preparation needs to be determined.

全文:

受限制的访问

作者简介

Elena Grudnitskaya

Institute of Advanced Training and Retraining of Healthcare Personnel, Belarusian State Medical University

编辑信件的主要联系方式.
Email: grudnickaja@mail.ru
ORCID iD: 0009-0003-5268-4029

PhD, Associate Professor, Associate Professor of the Department of Obstetrics and Gynecology

白俄罗斯, Minsk

Larysa Nebyshynets

Institute of Advanced Training and Retraining of Healthcare Personnel, Belarusian State Medical University

Email: larisa_minsk08@mail.ru
ORCID iD: 0009-0002-3966-4173

PhD, Associate Professor, Head of the Department of Obstetrics and Gynecology

白俄罗斯, Minsk

参考

  1. Недифференцированные дисплазии соединительной ткани (проект клинических рекомендаций). Терапия. 2019; 5(7): 9-42. [Undifferentiated connective tissue dysplasia (the project of guidelines). Therapy. 2019; 5(7); 9-42. (in Russian)]. https://dx.doi.org/10.18565/therapy.2019.7.9-42.
  2. Фадеева Т.С., Молоканова М.В., Павлов О.Г. Влияние степени тяжести недифференцированной дисплазии соединительной ткани на течение беременности. Вестник новых медицинских технологий. Электронное издание. 2019; 3: 12-7. [Fadeeva T.S., Molokanova M.V., Pavlov O.G. The influence of the severity of undifferentiated connective tissue dysplasia on pregnancy. Journal of New Medical Technologies, eEdition. 2019; (3): 12-7. (in Russian)]. https://dx.doi.org/10.24411/2075-4094-2019-16395.
  3. Смирнова Т.Л., Герасимова Л.И., Сидоров А.Е., Чернышов В.В., Губанова Е.А. Особенности течения беременности и родов у женщин с синдромом недифференцированной дисплазии соединительной ткани. Практическая медицина. 2018; 16(6): 39-44. [Smirnova T.L., Gerasimova L.I., Sidorov A.E., Chernyshov V.V., Gubanova E.A. Features of the course of pregnancy and childbirth in women with syndrome of undifferentiated connective tissue dysplasia. Practical Medicine. 2018; 16(6): 39-44. (in Russian)]. https://dx.doi.org/10.32000/2072-1757-2018-16-6-39-44.
  4. Devereux R.B., de Simone G., Arnett D.K., Best L.G., Boerwinkle E., Howard B.V. et al. Normal limits in relation to age, body size and gender of two-dimensional echocardiographic aortic root dimensions in persons ≥15 years of age. Am. J. Cardiol. 2012; 110(8): 1189-94. https://dx.doi.org/10.1016/j.amjcard.2012.05.063.
  5. Министерство здравоохранения Республики Беларусь, Белорусское научное общество кардиологов, Белорусский государственный медицинский университет. Диагностика и лечение наследственных и многофакторных нарушений соединительной ткани. Национальные клинические рекомендации. Минск; 2014. 75c. [Ministry of Health of the Republic of Belarus, Belarusian Scientific Society of Cardiology, Belarusian State Medical University. Diagnosis and treatment of hereditary and multifactorial connective tissue disorders. National clinical guidelines. Minsk; 2014. 75p. (in Russian)].
  6. Du Bois D., Du Bois E.F. A formula to estimate the approximate surface area if height and weight be known. Arch. Intern. Med. 1916; 17: 863-71.
  7. ESHRE Guideline Group on RPL; Bender Atik R., Christiansen O.B., Elson J., Kolte A.M., Lewis S., Middeldorp S. et al. ESHRE guideline: recurrent pregnancy loss: an update in 2022. Hum. Reprod. Open. 2023; 2023(1): hoad002. https://dx.doi.org/10.1093/hropen/hoad002.
  8. Холматова К.К., Горбатова М.А., Харькова О.А., Гржибовский А.М. Поперечные исследования: планирование, размер выборки, анализ данных. Экология человека. 2016; 2: 49-56. [Kholmatova K.K., Gorbatova M.A., Kharkova O.A., Grjibovski A.M. Cross-sectional studies: planning, sample size, data analysis. Human Ecology. 2016; (2): 49-56. (in Russian)].
  9. Айрапетов Д.Ю. Значение недифференцированной дисплазии соединительной ткани в формировании женского бесплодия. Акушерство и гинекология. 2008; 2: 47-9. [Airapetov D.Yu. Value of undifferentiated connective tissue dysplasia in the development of female infertility. Obstetrics and Gynecology. 2008; (2): 47-9. (in Russian)].
  10. Сметанин М.Ю., Пименов Л.Т., Чернышова Т.Е., Кононова Н.Ю. Оценка обеспеченности витамином D у женщин репродуктивного возраста с дисплазией соединительной ткани. Терапия. 2019; 7: 81-3. [Smetanin M.Yu., Pimenov L.T., Chernyshova T.E., Kononova N.Yu. Assessment of vitamin d in women of reproductive age with connective tissue dysplasia. Therapy. 2019; (7): 81-3 (in Russian)]. https://dx.doi.org/10.18565/therapy.2019.7.81-83.
  11. Смольнова Т.Ю., Адамян Л.В. Динамика фенотипических признаков синдрома дисплазии соединительной ткани в различные возрастные периоды. Актуальность проблемы в акушерстве и гинекологии. Акушерство и гинекоогия. 2013; 4: 74-9. [Smolnova T.Yu., Adamyan L.V. Time course of changes in the phenotypic signs of connective tissue dysplasia at different ages: the urgency of the problem in obstetrics and gynecology. Obstetrics and Gynecology. 2013; (4): 74-9. (in Russian)].
  12. Джулай Т.Е., Джулай Г.С. Прогностическое значение диспластозависимых фенотипических и висцеральных проявлений при гастроэзофагеальной рефлюксной болезни, ассоциированной с дуоденогастроэзофагеальным рефлюксом. Экспериментальная и клиническая гастроэнтерология. 2022; 200(4): 41-7. [Dzhulay T.E., Dzhulay G.S. Predictive value of dysplastic-dependent phenotypic and visceral manifestations in gastroesophageal reflux disease associated with duodenogastroesophageal reflux. Experimental and Clinical Gastroenterology. 2022; 200(4): 41-7. (in Russian)]. https://dx.doi.org/10.31146/1682-8658-ecg-200-4-41-47.
  13. Фадеева Т.С. Дисплазия соединительной ткани: новые горизонты проблемы: монография. Чебоксары: ИД «Среда»; 2018.76с. [Fadeeva T.S. Connective tissue dysplasia: new horizons of the problem: monograph. Cheboksary: Publishing House "Sreda"; 2018. 76p. (in Russian)].
  14. Смирнова Т.Л., Герасимова Л.И. Особенности клинических проявлений синдрома недифференцированной дисплазии соединительной ткани. Доктор.Ру. 2018; 8: 40-4. [Smirnova T.L., Gerasimova L.I. Specific clinical features of undifferentiated connective tissue dysplasia syndrome. Doctor.Ru. 2018; (8): 40-4. (in Russian)]. https://dx.doi.org/10.31550/1727-2378-2018-152-8-40-44.
  15. Сметанин М.Ю., Пименов Л.Т., Чернышова Т.Е. Гормональный профиль и показатели минерального обмена у женщин с дисплазией соединительной ткани. Практическая медицина. 2018; 1: 140-3. [Smetanin M.Yu., Pimenov L.T., Chernyshova T.E. Hormonal profile and indicators of mineral metabolism in women with connective tissue dysplasia. Practical Medicine. 2018; (1): 140-3. (in Russian)].

补充文件

附件文件
动作
1. JATS XML
下载
2. Figure. Study design

下载 (335KB)
索引源数据

版权所有 © Bionika Media, 2024
##common.cookie##