Exploration of the association between gonadotropin genes and their receptor gene variants and the development of polycystic ovary syndrome

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective: To evaluate the association between gonadotropin genes and their receptor gene variants with the development of polycystic ovary syndrome (PCOS).

Materials and methods: The study included 112 women. The main group comprised 57 women with PCOS, and the control group comprised 55 women. Exploration of gene variants NM_000894.3(LHB): c. 364G>A (p. Gly122Ser), rs5030774; NM_001382289. 1(FSHB):c.236_237del(p.Val79fs), rs5030646 and NC_000011.10:g.30204981G>A, rs11031006; NM_000233.4 (LHCGR):c.537-235G>A, rs4953616; NM_000145. 4(FSHR):c.919G>A(p.Ala307Thr), rs6165 was performed using allele-specific real-time PCR method followed by statistical data processing.

Results: Our study found no association between PCOS and the variant rs5030774 in the LHB gene and the variant rs5030646 in the FSHB gene. Statistically significant differences were found between the groups under study in distribution of alleles and genotypes across the variant rs11031006 in the FSHB gene, rs4953616 in the LHCGR gene, and rs6165 in the FSHR gene. Allele frequencies of the FSHB A rs11031006 and the FSHR T rs6165 were higher in the control group (59/110 (53.6%) at p=0.008 (OR=0.485, 95% CI 0.284–0.829) and 86/110 (78.2%) at p=0.014 (OR=0.478, 95% CI 0.265–0.864), respectively, while the prevalence of the allele T rs4953616 of the LHCGR gene was higher in the group of patients with PCOS compared with the control group (87/114 (76,3%) at p=0.002 (OR=2.404, 95% CI 1.354–4.267)).

Conclusion: Exploration of polymorphic loci of gonadotropin genes and their receptor gene variants showed statistically significant association between PCOS and rs11031006 in the FSHB gene, rs4953616 in the LHCGR gene, and rs6165 in the FSHR gene.

Толық мәтін

Рұқсат жабық

Авторлар туралы

K. Ustenko

Rostov State Medical University, Ministry of Health of Russia

Email: ustenko.ksusha@gmail.com
ORCID iD: 0009-0003-3992-1923

student

Ресей, Rostov-on-Don

E. Derevyanchuk

Southern Federal University

Хат алмасуға жауапты Автор.
Email: biolab2008@yandex.ru
ORCID iD: 0000-0002-6231-3454

PhD, Associate Professor

Ресей, Rostov-on-Don

A. Aleksandrova

Southern Federal University

Email: aalexsandrova@mail.ru
ORCID iD: 0000-0002-1948-4995

PhD, Associate Professor

Ресей, Rostov-on-Don

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