IMMUNO-HORMONAL INTERACTIONS IN GENESIS OF EARLY PREGNANCY LOSS

Objective. Finding out significant pathogenetical changes of immune system and development of immunological prognostic criteria for spontaneous abortion in women with recurrent pregnancy loss due to hormonal disbalance to reduce frequency of perinatal complications. Materials and methods. 116 women with early pregnancy underwent examination. Among them, there are 59 women with recurrent pregnancy loss — study group - and 57 women with physiological pregnancy — control group. Population and subpopulation composition of peripheral blood, expression of the markers of activation and apoptosis, receptors toIL-4 (CD124), level of IL-1ß, IL-2, IL-4, IL-10, TNF-α, IFN-γ, activin-А, neopterin, steroids hormones( estriol, progesterone, chorionic gonadotropins ) in the blood were studied. Results. The significant cause of recurrent pregnancy loss associated with hormonal impairments of feto-maternal complex is disbalance of activation and apoptosis processes. Increasing of neopterin, shifting of cytokine balance to increasing proinflammatory cytokine synthesis in the blood, that associated to decreasing amount of lymphocytes, expressed receptor to IL-4, and increasing activine-А production. Revealed immune shifts indicate modulating effect of steroids hormones, which proves immune-hormonal homeostasis impairments and may be the markers of threaten abortions in women with hormonal disbalance of feto-placental complex. Comclusion. With the help of immune criteria prognosis algorithm of spontaneous abortion in women with recurrent fetal loss due to hormonal impairments of feto-placental complex was developed. This will help to choose an adequate and timely treatment and also prophylaxis measures against perinatal complications, which increase cases of favorable obstetrical outcomes.

recurrent pregnancy loss, spontaneous abortion, hormonal disbalance, cytokines, immune status