ROLE OF AUTONOMIC REGULATION IN THE PATHOGENESIS OF DIFFUSE BREAST DYSPLASIA

Objective. To assess the implication of the autonomic nervous system (ANS) in the pathogenesis of diffuse dyshormonal breast dysplasia and the possibilities of mastodynon correction of autonomic dysfunction. Subject and methods. Twenty hundred and five women with diffuse dyshormonal breast dysplasia and 45 healthy women underwent comprehensive evaluation of ANS by questioning, cardiac intervalography, and autonomic testing along with hormone analysis. Results. The reduced total power spectrum of neurohumoral modulation and activated humoral, metabolic, and sympathetic effects on heart rate regulation were established for each form of mastopathy. The high efficiency of therapy with mastodynon is determined by not only the normalization of prolactin levels, but also by the arrest of autonomic dysfunction. Conclusion. The f indings can optimize therapy for diffuse dyshormonal breast dysplasia, by affecting the ANS, which is a pathogenetic component of the occurrence and progression of the disease.

benign breast pathology, autonomic disorders, diffuse breast dysplasia, mastodynon