NEONATAL MANIFESTATION OF INHERITED HYPOPITUITARISM


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Аннотация

Background. Inherited hypopituitarism is a disease characterized by hypothalamic or pituitary malfunction with the decreased or ceased production of one or a few tropic hormones. Despite the congenital pattern of the pathology, the clinical picture of hormone deficiency is frequently obscure in infants, leading to its late diagnosis. Neonatality is marked by the development of hypoglycemic states, cholestatic syndrome, muscular hypotonia and related respiratory disorders. Description. The paper describes a clinical case of an infant with the neonatal manifestation of hypopituitarism, the main clinical signs of which were recurrent hypoglycemias, progressive diffuse muscular hypotonia, and progressive cholestatic syndrome. Hormone replacement therapy improved the infant’s state and relieved glycemic episodes and respiratory disorders. Skin icteritiousness was diminished, the liver reduced in size, and blood biochemical parameters showed positive changes. Conclusion. The early diagnosis of hypopituitarism and its timely treatment substantially improve the prognosis of the disease.

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Авторлар туралы

A. RYNDIN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_ryndin@oparina4.ru
Moscow

O. IONOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: o_ionov@oparina4.ru
Moscow

E. KIRILLOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kirillova@oparina4.ru
Moscow

A. DEGTYAREVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_degtyareva@oparina4.ru
Moscow

M. MELIKYAN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: m_melikyan@oparina4.ru
Moscow

L. SHARIPOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: l_sharipova@oparina4.ru
Moscow

E. BALASHOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_balashova@oparina4.ru
Moscow

N. EVTEEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: y_onishchenko@oparina4.ru
Moscow

Yu. ONISHCHENKO

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Moscow

Әдебиет тізімі

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