PREGNANCY IN IN-SITU AND MICROINVASIVE CARCINOMA OF THE UTERINE CERVIX: CHANCES OF CARRYING PREGNANCY TO FULL TERM, SPECIFIC FEATURES OF DIAGNOSIS AND DISEASE COURSE, AND OUTCOMES AND PROGNOSIS


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective. To study the frequency of errors of a cytological method during pregnancy in suspected carcinoma of the uterine cervix in the smears and in the absence of a visible tumor and to determine the chance of carrying pregnancy to full term in the presence of in-situ (CIN3/CIS) and microinvasive carcinoma of the uterine cervix (MICUS). Subjects and methods. The study enrolled 102 pregnant women without visual signs of a tumor with high-grade squamous intraepithelial lesion (HSIL+) and cancer cells in the smears. Their study involved reexamination of ready cytology specimens and smears, expanded colposcopy, and a virological test for high-risk human papillomavirus (HPV) using chain polymerase reaction and hybrid capture 2 (HC2), as well as histological examination of biopsy and conization specimens during pregnancy and postpartum. Results. Out of 102 pregnant women, 43 (42.2%) were histologically found to have CIN1-2, koilocytosis; only 59 (57.8%) pregnant women with CIN3/CIS (n = 48) and MICUS without lymphovascular invasion (n = 11) were at risk for progression when carrying pregnancy to full term. Out of them, 58 patients decided to preserve pregnancy, 56 favorably carried it and gave birth to a full-term baby. Electrosurgical high-frequency conization was performed in 11 pregnant women in the second trimester and in all the patients 6-8 weeks after pregnancy termination. They fully recovered and had no disease progression. The patients are alive with no signs of incurability during follow-ups of 6 to 72 months. Conclusion. Cytological hyperdiagnosis of the degree of neoplasia is noted during pregnancy. Patents with CIN3/CIS and MICUS may carry pregnancy to full term with a favorable outcome in the fetus and the patient. Postpartum conization is sufficient to cure the majority of patients.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Lyubov Korolenkova

N.N. Blokhin Russian Cancer Research Center, Federal Agency of Research Organizations

Email: l.korolenkova@mail.ru
MD, senior researcher of the scientific advisory 115478, Russia, Moscow, Kashirskoye shosse 24

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