TREATMENT FOR MENOPAUSAL DISORDERS

Objective. To evaluate the efficiency and safety of menoril plus used long as a prophylactic medication for recovery of menstrual function and treatment of mild early menopausal disorders. Subjects and methods. The investigation Included 60 women aged 36- 45 years (their mean age was 40.5±0.2 years). All the patients were given menoril plus at a dose of 1 capsule twice a day during a meal for 12 months (the daily dose of genistein was 30 mg). Its efficacy was evaluated after 3, 6, 9, and 12 months of a follow-up. The clinical efficacy was evaluated by the following criteria: improved quality of life (by a 5-point system) and no effect; analysis of the patients’ complaints before treatment and over time. Results. The majority of patients (n = 33) reported clinical improvement and the absence of the major autonomic vascular manifestation of the climacteric symptom - sweating just by the first month of treatment; the patients with this complaint were 100% at 3 months of therapy. Menstrual function recovered more slowly; at 3 months, the patients complaining of a shorter menstrual cycle were 49% and those who complained of oligomenorrhea were 44% of the total number of the patients; by the end of the first year of treatment, such patients were 6 and 12%, respectively. Small pelvic ultrasonography carried out in phase 1 of the menstrual cycle to evaluate the endometrium and ovarian function could indicate that long continuously used menoril plus had no effect on endometrial and proliferative processes. Analysis of the health status and better quality of life in accordance with the 5-point scale showed that 49 (81%) patients noted improvement by 5 scores, accounting for 82%; 7 (12%) patients assessed treatment effects by 4 scores; 2 (3%) patients reported that their treatment was ineffective. Conclusion. One-year use of menoril plus in late reproductive-aged women with primary menstrual irregularities and the first manifestations of their mild early symptoms substantially improves their general condition due to the disappearance and reduction of autonomic vascular and psychoemotional disorders and to gradual normalization of menstrual function.

menopausal syndrome, prevention, early symptoms, menoril plus