REPEATED IMPLANTATION FAILURES IN AN IVF PROGRAM: IMMUNOLOGICAL ASPECTS


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Objective. To carry out a systematic analysis of the data available in modern literature on the immunological aspects of repeated implantation failures in an IVF program, as well as on current personalized immunotherapies to overcome repeated implantation failures. Material and methods. The review includes the data of foreign and Russian papers published in 2010-2016 and found in Pubmed on this topic. These articles have become the basis for this review; however, for better understanding of the topic, the authors have expanded the search and included older articles that are widely cited. Conclusion. There is substantial evidence that the impaired expression of nonclassical HLA molecules, cytokine imbalance, and changes in the number and activity of NK cells may contribute to reproductive dysfunction. A more complete understanding of hormonal modulation of the immune microenvironment of the endometrium will be able to elaborate new personalized therapeutic approaches to preventing repeated implantation failures.

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Sobre autores

T. AMYAN

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: amyantanya@rambler.ru
a graduate student of the 1st year of study department of conservation and restoration of reproductive function Moscow 117997, Ac. Oparina str. 4, Russia

S. PERMINOVA

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: perisvet@list.ru
MD, a leading researcher department of conservation and restoration of reproductive function Moscow 117997, Ac. Oparina str. 4, Russia

L. KRECHETOVA

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: k_l_v_@mail.ru
PhD, Senior Research Fellow, Head of the Laboratory Laboratory of Clinical Immunology Moscow 117997, Ac. Oparina str. 4, Russia

V. VTORUSHINA

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: vtorushina@inbox.ru
PhD, doctor of clinical laboratory diagnostics Moscow 117997, Ac. Oparina str. 4, Russia

E. MITYURINA

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Candidate of Medical Sciences, department of conservation and restoration of reproductive function Moscow 117997, Ac. Oparina str. 4, Russia

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