Different clinical forms of vulvovaginal candidiasis: Principles of treatment

Objective. To improve treatments for different clinical forms of VVC. Subjects and methods. A total of 105 women, including 85patients with Candida infection a study group) and 20 healthy women (a control group), were examined. All the women underwent bacterioscopic and bacteriological examinations to detect the bacterial and Candida microflora. A Candiselect-4 diagnostic kit (Bio-Rad, USA) was used to determine yeast fungal species and concentration. The patients with Candida infection were divided into 2 groups: 1) 70patients with Candida monoinfection; 2) 15patients with mixed bacterial and Candida infection. Results and discussion. All the patients received sertaconazole (zalain), a derivative of benzothiophene and imidazole, having fungistatic and fungicidal effects on fungi and antibacterial activity. The drug was administered as one 300-mg vaginal suppository weekly overnight or in combination with zalain cream Conclusion. The investigations have indicated that sertaconazole (zalain) has a high (94%) activity against any type of vaginal candidiasis in both monoinfection and mixed Candida and bacterial infection. By acting not only on Candida albicans, but also on non-Candida albicans, the drug rapidly resolves the clinical manifestations in the acute and chronic course of the disease, which together with the absence of adverse reactions allows one to recommend its use in patients with different clinical forms of vulvovaginitis.

vulvovaginal candidiasis, Sertaconazole (zalain)